Dysregulation of apoptosis as a mechanism of liver disease: An overview

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Abstract

Apoptosis is a morphologically distinct form of cell death which occurs in a wide variety of liver diseases. In this overview chapter, we review: (1) the current definitions of apoptosis; (2) the biochemical pathways effecting apoptosis; and (3) the intracellular pathways regulating apoptosis. We also describe how apoptosis is identified in the liver and review the ligand/receptor interactions which trigger hepatobiliary apoptosis. Finally, we speculate on potential therapeutic applications for modulating apoptosis in human liver diseases. This information is meant to provide a foundation for the following chapters each focused on a specific role of apoptosis in liver diseases.

Original languageEnglish (US)
Pages (from-to)105-114
Number of pages10
JournalSeminars in liver disease
Volume18
Issue number2
DOIs
StatePublished - 1998

Keywords

  • Bcl-2
  • Death receptors
  • Fas
  • Mitochondria
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Hepatology

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