Dysregulation of apoptosis as a mechanism of liver disease: An overview

Tushar Patel; Lewis R. Roberts; Blake A. Jones; Gregory J. Gores

doi:10.1055/s-2007-1007147

Dysregulation of apoptosis as a mechanism of liver disease: An overview

Tushar Patel, Lewis R. Roberts, Blake A. Jones, Gregory J. Gores

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

Apoptosis is a morphologically distinct form of cell death which occurs in a wide variety of liver diseases. In this overview chapter, we review: (1) the current definitions of apoptosis; (2) the biochemical pathways effecting apoptosis; and (3) the intracellular pathways regulating apoptosis. We also describe how apoptosis is identified in the liver and review the ligand/receptor interactions which trigger hepatobiliary apoptosis. Finally, we speculate on potential therapeutic applications for modulating apoptosis in human liver diseases. This information is meant to provide a foundation for the following chapters each focused on a specific role of apoptosis in liver diseases.

Original language	English (US)
Pages (from-to)	105-114
Number of pages	10
Journal	Seminars in liver disease
Volume	18
Issue number	2
DOIs	https://doi.org/10.1055/s-2007-1007147
State	Published - 1998

Keywords

Bcl-2
Death receptors
Fas
Mitochondria
Tumor necrosis factor-α

ASJC Scopus subject areas

Hepatology

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10.1055/s-2007-1007147

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abstract = "Apoptosis is a morphologically distinct form of cell death which occurs in a wide variety of liver diseases. In this overview chapter, we review: (1) the current definitions of apoptosis; (2) the biochemical pathways effecting apoptosis; and (3) the intracellular pathways regulating apoptosis. We also describe how apoptosis is identified in the liver and review the ligand/receptor interactions which trigger hepatobiliary apoptosis. Finally, we speculate on potential therapeutic applications for modulating apoptosis in human liver diseases. This information is meant to provide a foundation for the following chapters each focused on a specific role of apoptosis in liver diseases.",

keywords = "Bcl-2, Death receptors, Fas, Mitochondria, Tumor necrosis factor-α",

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year = "1998",

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AU - Jones, Blake A.

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PY - 1998

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AB - Apoptosis is a morphologically distinct form of cell death which occurs in a wide variety of liver diseases. In this overview chapter, we review: (1) the current definitions of apoptosis; (2) the biochemical pathways effecting apoptosis; and (3) the intracellular pathways regulating apoptosis. We also describe how apoptosis is identified in the liver and review the ligand/receptor interactions which trigger hepatobiliary apoptosis. Finally, we speculate on potential therapeutic applications for modulating apoptosis in human liver diseases. This information is meant to provide a foundation for the following chapters each focused on a specific role of apoptosis in liver diseases.

KW - Bcl-2

KW - Death receptors

KW - Fas

KW - Mitochondria

KW - Tumor necrosis factor-α

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JO - Seminars in liver disease

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ER -

Dysregulation of apoptosis as a mechanism of liver disease: An overview

Abstract

Keywords

ASJC Scopus subject areas

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