Dyspnea in a young woman with chest radiography showing large lung volumes

Michael B. Gotway, Jessica W.T. Leung

Research output: Contribution to journalArticle

Abstract

Lymphangioleiomyomatosis is a rare pulmonary disorder that almost exclusively affects women of childbearing age. Histopathological findings of LAM are very similar to tuberous sclerosis, raising the possibility that LAM is a forme fruste of TS. Chest radiographic findings of LAM include large lung volumes with bilaterally symmetric linear and/or reticular abnormalities or direct visualization of the pulmonary cysts. HRCT in patients with LAM shows numerous thin-walled, regular cysts without a zonal predominance. Pleural effusions may occur in patients with LAM, and pneumothorax may be the presenting feature of the disease in a number of patients. The diagnosis of LAM may be established with transbronchial or surgical lung biopsy, although a tissue diagnosis may be avoided in patients with sufficiently characteristic clinical, laboratory, and HRCT findings.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalClinical Pulmonary Medicine
Volume12
Issue number2
DOIs
StatePublished - Mar 1 2005

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Keywords

  • Cyst
  • High-resolution CT
  • Langerhans cell histiocytosis
  • Lymphangioleiomyomatosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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