Dyspepsia and dyspepsia subgroups: A population-based study

Nicholas J. Talley, Alan R. Zinsmeister, Cathy D. Schleck, L. Joseph Melton

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672 Citations (Scopus)

Abstract

It has been proposed that patients with dyspepsia can be classified into symptom groupings that may represent different pathophysiological entities, however, it remains to be shown that distinct symptom subgroups exist. To estimate the prevalence of dyspepsia (defined as upper abdominal pain) and dyspepsia subgroups, an age-and sex-stratified random sample of Olmsted County, Minnesota, residents, aged 30-64 years, were mailed a valid self-report questionnaire, 82% responded (n = 835). Subgroups were as follows, those with symptoms suggestive of peptic ulceration (ulcerlike dyspepsia), those with gastric stasis (dysmotilitylike dyspepsia), those with gastroesophageal reflux (refluxlike dyspepsia), and the remainder (unspecified dyspepsia). Ulcerlike dyspepsia was the commonest subgroup (prevalence, 16.0/100, 95% confidence interval, 13.4-18.5), but 43% of subjects with dyspepsia could be classified into more than one subgroup. Nearly one third of dyspeptics also had irritable bowel symptoms, but these were not confined to any particular dyspepsia subgroup. Although dyspepsia is very common in the community and the majority have ulcerlike symptoms, there is such overlap among the dyspepsia subgroups that a classification based on symptoms alone in uninvestigated patients may not be useful.

Original languageEnglish (US)
Pages (from-to)1259-1268
Number of pages10
JournalGastroenterology
Volume102
Issue number4 PART 1
StatePublished - 1992

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Dyspepsia
Population
Gastroparesis
Gastroesophageal Reflux
Self Report
Abdominal Pain
Digestion
Confidence Intervals

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Talley, N. J., Zinsmeister, A. R., Schleck, C. D., & Melton, L. J. (1992). Dyspepsia and dyspepsia subgroups: A population-based study. Gastroenterology, 102(4 PART 1), 1259-1268.

Dyspepsia and dyspepsia subgroups : A population-based study. / Talley, Nicholas J.; Zinsmeister, Alan R.; Schleck, Cathy D.; Melton, L. Joseph.

In: Gastroenterology, Vol. 102, No. 4 PART 1, 1992, p. 1259-1268.

Research output: Contribution to journalArticle

Talley, NJ, Zinsmeister, AR, Schleck, CD & Melton, LJ 1992, 'Dyspepsia and dyspepsia subgroups: A population-based study', Gastroenterology, vol. 102, no. 4 PART 1, pp. 1259-1268.
Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ. Dyspepsia and dyspepsia subgroups: A population-based study. Gastroenterology. 1992;102(4 PART 1):1259-1268.
Talley, Nicholas J. ; Zinsmeister, Alan R. ; Schleck, Cathy D. ; Melton, L. Joseph. / Dyspepsia and dyspepsia subgroups : A population-based study. In: Gastroenterology. 1992 ; Vol. 102, No. 4 PART 1. pp. 1259-1268.
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