Dysmotility of the small intestine in irritable bowel syndrome

J. E. Kellow, S. F. Phillips, Laurence J Miller, A. R. Zinsmeister

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Though the pathophysiology of the irritable bowel syndrome (IBS) is commonly attributed to dysfunction of the large intestine, evidence exists to incriminate the small bowel. In order to further explore the role of the small bowel in IBS several stimuli were applied, in an attempt to unmask the dysmotility of the jejunum and ileum. These included infusions of cholecystokinin-octapeptide (CCK-OP), a high fat meal, neostigmine and balloon distension of the ileum. Three groups (n=8) each of age and sex matched healthy volunteers were studied; patients with IBS complained of predominant constipation (n=8) or diarrhoea (n=8). Patients with IBS responded excessively to stimulation by CCK-OP, fatty meal, and ileal distension. In general patients with diarrhoea were more sensitive to stimuli than those with constipation. The ileum responded more to stimulation than the jejunum. As in the large bowel, stimuli appear to unmask intestinal dysmotility in patients with IBS. Motor abnormalities were often accompanied by abdominal symptoms, raising the possibility that dysfunction of the small bowel contributes to the symptoms of IBS.

Original languageEnglish (US)
Pages (from-to)1236-1243
Number of pages8
JournalGut
Volume29
Issue number9
DOIs
StatePublished - 1988

Fingerprint

Irritable Bowel Syndrome
Small Intestine
Ileum
Sincalide
Jejunum
Constipation
Meals
Diarrhea
Neostigmine
Large Intestine
Healthy Volunteers
Fats

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Kellow, J. E., Phillips, S. F., Miller, L. J., & Zinsmeister, A. R. (1988). Dysmotility of the small intestine in irritable bowel syndrome. Gut, 29(9), 1236-1243. https://doi.org/10.1136/gut.29.9.1236

Dysmotility of the small intestine in irritable bowel syndrome. / Kellow, J. E.; Phillips, S. F.; Miller, Laurence J; Zinsmeister, A. R.

In: Gut, Vol. 29, No. 9, 1988, p. 1236-1243.

Research output: Contribution to journalArticle

Kellow, JE, Phillips, SF, Miller, LJ & Zinsmeister, AR 1988, 'Dysmotility of the small intestine in irritable bowel syndrome', Gut, vol. 29, no. 9, pp. 1236-1243. https://doi.org/10.1136/gut.29.9.1236
Kellow, J. E. ; Phillips, S. F. ; Miller, Laurence J ; Zinsmeister, A. R. / Dysmotility of the small intestine in irritable bowel syndrome. In: Gut. 1988 ; Vol. 29, No. 9. pp. 1236-1243.
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