Dysfunctions of the stomach with gastric ulceration

Laurence J Miller, Juan R. Malagelada, George F. Longstreth, Vayliang W. Go

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Factors implicated in the pathogenesis of gastric ulcer were studied simultaneously in seven patients with strictly defined type 1 gastric ulcer (single benign ulcer above the incisura of the stomach) and in six healthy controls. After ingestion of an ordinary solid-liquid meal, patients with gastric ulcer demonstrated gastric hyposecretion of acid, pepsin, and water; delayed gastric emptying of solids with normal emptying of liquids; and increased intragastric concentrations of bile acids. These functional abnormalities appear to be interrelated. Metoclopramide, administered orally in a double-blind fashion, ameliorated the defect in the emptying of solids and the high concentrations of bile acid in the gastric contents. The ability of this drug to break this interdependent cycle suggests the need for further clinical investigation.

Original languageEnglish (US)
Pages (from-to)857-864
Number of pages8
JournalDigestive Diseases and Sciences
Volume25
Issue number11
DOIs
StatePublished - Nov 1980

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Stomach Ulcer
Stomach
Bile Acids and Salts
Gastrointestinal Contents
Metoclopramide
Pepsin A
Gastric Emptying
Gastric Acid
Ulcer
Meals
Eating
Water
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Dysfunctions of the stomach with gastric ulceration. / Miller, Laurence J; Malagelada, Juan R.; Longstreth, George F.; Go, Vayliang W.

In: Digestive Diseases and Sciences, Vol. 25, No. 11, 11.1980, p. 857-864.

Research output: Contribution to journalArticle

Miller, LJ, Malagelada, JR, Longstreth, GF & Go, VW 1980, 'Dysfunctions of the stomach with gastric ulceration', Digestive Diseases and Sciences, vol. 25, no. 11, pp. 857-864. https://doi.org/10.1007/BF01338528
Miller, Laurence J ; Malagelada, Juan R. ; Longstreth, George F. ; Go, Vayliang W. / Dysfunctions of the stomach with gastric ulceration. In: Digestive Diseases and Sciences. 1980 ; Vol. 25, No. 11. pp. 857-864.
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