DyNeuMo Mk-2: An Investigational Circadian-Locked Neuromodulator with Responsive Stimulation for Applied Chronobiology

Robert Toth, Mayela Zamora, Jon Ottaway, Tom Gillbe, Sean Martin, Moaad Benjaber, Guy Lamb, Tara Noone, Barry Taylor, Alceste Deli, Vaclav Kremen, Gregory Worrell, Timothy G. Constandinou, Ivor Gillbe Stefan De Wachter, Charles Knowles, Andrew Sharott, Antonio Valentin, Alexander L. Green, Timothy Denison

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Deep brain stimulation (DBS) for Parkinson's disease, essential tremor and epilepsy is an established palliative treatment. DBS uses electrical neuromodulation to suppress symptoms. Most current systems provide a continuous pattern of fixed stimulation, with clinical follow-ups to refine settings constrained to normal office hours. An issue with this management strategy is that the impact of stimulation on circadian, i.e. sleep-wake, rhythms is not fully considered; either in the device design or in the clinical follow-up. Since devices can be implanted in brain targets that couple into the reticular activating network, impact on wakefulness and sleep can be significant. This issue will likely grow as new targets are explored, with the potential to create entraining signals that are uncoupled from environmental influences. To address this issue, we have designed a new brain-machine-interface for DBS that combines a slow-adaptive circadian-based stimulation pattern with a fast-acting pathway for responsive stimulation, demonstrated here for seizure management. In preparation for first-in-human research trials to explore the utility of multi-timescale automated adaptive algorithms, design and prototyping was carried out in line with ISO risk management standards, ensuring patient safety. The ultimate aim is to account for chronobiology within the algorithms embedded in brain-machine-interfaces and in neuromodulation technology more broadly.

Original languageEnglish (US)
Title of host publication2020 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3433-3440
Number of pages8
Volume2020-October
ISBN (Electronic)9781728185262
DOIs
StatePublished - Oct 11 2020
Event2020 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2020 - Toronto, Canada
Duration: Oct 11 2020Oct 14 2020

Conference

Conference2020 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2020
Country/TerritoryCanada
CityToronto
Period10/11/2010/14/20

Keywords

  • Activity recognition
  • Adaptive control
  • Brain stimulation
  • Chronobiology
  • Circadian rhythm
  • Closed loop systems
  • Digital filters
  • Neural implants
  • Safety management

ASJC Scopus subject areas

  • Software
  • Control and Systems Engineering
  • Human-Computer Interaction
  • Computer Science Applications
  • Electrical and Electronic Engineering

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