Dynamics of multiple myeloma tumor therapy with a recombinant measles virus

D. Dingli, C. Offord, R. Myers, K. W. Peng, T. W. Carr, K. Josic, S. J. Russell, Z. Bajzer

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Replication-competent viruses are being tested as tumor therapy agents. The fundamental premise of this therapy is the selective infection of the tumor cell population with the amplification of the virus. Spread of the virus in the tumor ultimately should lead to eradication of the cancer. Tumor virotherapy is unlike any other form of cancer therapy as the outcome depends on the dynamics that emerge from the interaction between the virus and tumor cell populations both of which change in time. We explore these interactions using a model that captures the salient biological features of this system in combination with in vivo data. Our results show that various therapeutic outcomes are possible ranging from tumor eradication to oscillatory behavior. Data from in vivo studies support these conclusions and validate our modeling approach. Such realistic models can be used to understand experimental observations, explore alternative therapeutic scenarios and develop techniques to optimize therapy.

Original languageEnglish (US)
Pages (from-to)873-882
Number of pages10
JournalCancer Gene Therapy
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2009

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Keywords

  • Mathematical modeling
  • Population dynamics
  • Tumor therapy
  • Viruses

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cancer Research

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