Dynamics of intramyocardial blood volume in the intact animal: evaluation with SPECT

Thomas Behrenbeck, Michael K. O'Connor, David A. Foley, Erik L M D Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Variations in blood volume in the myocardium through the cardiac cycle have previously been considered constant. More recent studies have indicated a considerably variation from end diastole to end systole. These studies were nearly all performed under non-physiological conditions using muscle preparations or ex situ cardiac preparations. This study was designed to assess the dynamic changes of the intramyocardial blood volume in the intact animal under normal flow conditions using single photon emission computed tomography (SPECT). Radiolabeled, 15 μm diameter, microspheres were emoblized in the myocardial microcirculation of dogs with subsequent scans in a TRIAD single-photon-emission-computed- tomography scanner. Gated images were obtained at 63 msec intervals encompassing the entire heart. Transmural voxel (= volume element) brightness was measured in all tomographic images reflecting global and regional count density in the myocardium. There was a significant decrease in the blood volume from end diastole to end systole (10.8 cc/100 mL muscle volume; p < 0.00001). The decrease from diastole (ED) to systole (ES) in image brightness at the apex, mid ventricle, and base were: -5.7% (p < 0.01, apex vs. base), -4.7% (p < 0.01, mid ventricle vs. base) and +2.2%, respectively. Conclusions: (1) respiratory and ECG gated SPECT images allow measurement of intramyocardial blood volume changes throughout the cardiac cycle in the intact animal; (2) myocardial blood content is maximum at ED; (3) these findings progressively diminished in magnitude from apex to base.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsEric A. Hoffman
Pages338-346
Number of pages9
Volume2709
StatePublished - 1996
EventMedical Imaging 1996: Physiology and Function from Multidimensional Images - Newport Beach, CA, USA
Duration: Feb 11 1996Feb 13 1996

Other

OtherMedical Imaging 1996: Physiology and Function from Multidimensional Images
CityNewport Beach, CA, USA
Period2/11/962/13/96

Fingerprint

Single photon emission computed tomography
blood volume
diastole
systole
animals
Animals
Blood
tomography
myocardium
apexes
evaluation
photons
muscles
brightness
Muscle
Luminance
preparation
cycles
dogs
Microcirculation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Behrenbeck, T., O&apos;Connor, M. K., Foley, D. A., & Ritman, E. L. M. D. (1996). Dynamics of intramyocardial blood volume in the intact animal: evaluation with SPECT. In E. A. Hoffman (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2709, pp. 338-346)

Dynamics of intramyocardial blood volume in the intact animal : evaluation with SPECT. / Behrenbeck, Thomas; O&apos;Connor, Michael K.; Foley, David A.; Ritman, Erik L M D.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Eric A. Hoffman. Vol. 2709 1996. p. 338-346.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Behrenbeck, T, O&apos;Connor, MK, Foley, DA & Ritman, ELMD 1996, Dynamics of intramyocardial blood volume in the intact animal: evaluation with SPECT. in EA Hoffman (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2709, pp. 338-346, Medical Imaging 1996: Physiology and Function from Multidimensional Images, Newport Beach, CA, USA, 2/11/96.
Behrenbeck T, O&apos;Connor MK, Foley DA, Ritman ELMD. Dynamics of intramyocardial blood volume in the intact animal: evaluation with SPECT. In Hoffman EA, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2709. 1996. p. 338-346
Behrenbeck, Thomas ; O&apos;Connor, Michael K. ; Foley, David A. ; Ritman, Erik L M D. / Dynamics of intramyocardial blood volume in the intact animal : evaluation with SPECT. Proceedings of SPIE - The International Society for Optical Engineering. editor / Eric A. Hoffman. Vol. 2709 1996. pp. 338-346
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