Dynamics of haemopoiesis across mammals

David Dingli, Arne Traulsen, Jorge M. Pacheco

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Haemopoiesis is a fundamental physiologic process found in many animals. Among mammals, the diversity in size and function required suitable adaptations of this process. In this work, we use allometric principles to determine whether this required a change in the basic architecture of haemopoiesis. We show that it is possible to express both the number and rate with which haemopoietic stem cells replicate as well as total marrow output across all mammals as a function of adult mass. This unified view, which is compatible with the existing data, suggests that there was no need for major adaptations in the architecture of haemopoiesis across mammals.

Original languageEnglish (US)
Pages (from-to)2389-2392
Number of pages4
JournalProceedings of the Royal Society B: Biological Sciences
Volume275
Issue number1649
DOIs
StatePublished - Oct 22 2008

Keywords

  • Allometry
  • Haemopoiesis
  • Scaling
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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