Dynamics of diastolic sounds caused by partially occluded coronary arteries

Metin Akay, Yasemin M. Akay, Dominique Gauthier, Robert G. Paden, William Pavlicek, F. David Fortuin, John P. Sweeney, Richard W. Lee

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


The aim of this project is to improve the detection of coronary occlusions using an approach based on the recording and analysis of isolated diastolic heart sounds associated with turbulent blood flow in occluded coronary arteries. The nonlinear dynamic analysis method based on approximate entropy has been proposed for the analysis of diastolic heart sounds. A commercially available electronic stethoscope was used to record the diastolic heart sounds from patients diagnosed with or without coronary artery disease (CAD) based on their coronary angiography examination. The nonlinear dynamical analysis (approximate entropy) measures of the diastolic heart sounds recorded from 30 patients with coronary occlusions and ten normal subjects were estimated. Results suggest the presence of the high nonlinear (approximate entropy) values of diastolic heart sounds associated with CAD ( p \hbox{0.05}). This approach led to a sensitivity of 77%, a specificity of 80%, and an overall accuracy of 78%. As a summary, 23 out of 30 abnormal patients and eight out of ten normal patients were correctly detected.

Original languageEnglish (US)
Article number4595685
Pages (from-to)513-517
Number of pages5
JournalIEEE Transactions on Biomedical Engineering
Issue number2
StatePublished - Feb 2009


  • Approximate entropy
  • Coronary artery disease (CAD)
  • Nonlinear dynamics analysis

ASJC Scopus subject areas

  • Biomedical Engineering


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