A computer based method has been developed for determination of the 3 dimensional spatial distribution of Xray absorption within moving organs, particularly the heart and lungs. Video recordings of multiplanar angiocardiographic images obtained during synchronous control of the heart rate, Xray exposure, and rotation of isolated working hearts and intact anesthetized dogs have been digitized to provide the data required for reconstruction of a temporal sequence of cross sections at 1/60 sec intervals throughout the cardiac cycle. Comparisons of these reconstructed cross sectional images with actual cross sectional slices indicate that the anatomic detail and spatial relation of the epicardial and endocardial surfaces of the heart and the parietal pleural surfaces of the thoracic cavity can be accurately reproduced over the full anatomic extent of the thorax. Reconstructions of the regional shapes and dimensions of the myocardium with such high spatial and temporal resolution, along with the simultaneous measurement of intracardiac and transmural pressures, provide the determinants required for estimations of the dynamic regional myocardial length tension relations that are necessary for objective assessment of cardiac contractility and reserve. It is believed that these techniques will add a powerful new dimension to investigative cardiovascular physiology and practical diagnostic cardiology.
|Original language||English (US)|
|Number of pages||6|
|Journal||Mayo Clinic proceedings|
|State||Published - Dec 1 1974|
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