Dynamic seizure imaging in patients with extratemporal lobe epilepsy

Yunfeng Lu, Lin Yang, Gregory Alan Worrell, Benjamin Brinkmann, Cindy Nelson, Bin He

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Epilepsy is a common neurological disease that affects about 50 million people worldwide. Extratemporal lobe epilepsy, which represents an important type of epilepsy, may involve seizure activity in various lobes and the surgical treatment in these patients tends to have less favorable surgical outcome. Noninvasive seizure imaging in drug-resistant patients is of vital importance to image the seizure onset zones (SOZs) and understand the mechanisms for an improved treatment plan. In this study, we directly imaged the seizure sources in 8 extratemporal lobe partial epilepsy patients from noninvasive EEG. The surgically resected regions and SOZs identified from intracranial EEG (iEEG) recordings were used to evaluate the source imaging results. All of the eight patients underwent resective surgery and the estimated seizure sources were co-located with the resection zone. Seven of the patients had iEEG recordings available and the source imaging results were concordant with the SOZs marked on the intracranial recording grid. The present results suggest that dynamic seizure imaging could be potentially useful to image the SOZs of extratemporal lobe seizures and help the pre-surgical planning of epilepsy patients.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages6228-6231
Number of pages4
DOIs
StatePublished - 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

Fingerprint

Epilepsy
Seizures
Electroencephalography
Imaging techniques
Surgery
Planning
Partial Epilepsy
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Lu, Y., Yang, L., Worrell, G. A., Brinkmann, B., Nelson, C., & He, B. (2012). Dynamic seizure imaging in patients with extratemporal lobe epilepsy. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 6228-6231). [6347417] https://doi.org/10.1109/EMBC.2012.6347417

Dynamic seizure imaging in patients with extratemporal lobe epilepsy. / Lu, Yunfeng; Yang, Lin; Worrell, Gregory Alan; Brinkmann, Benjamin; Nelson, Cindy; He, Bin.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2012. p. 6228-6231 6347417.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lu, Y, Yang, L, Worrell, GA, Brinkmann, B, Nelson, C & He, B 2012, Dynamic seizure imaging in patients with extratemporal lobe epilepsy. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS., 6347417, pp. 6228-6231, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012, San Diego, CA, United States, 8/28/12. https://doi.org/10.1109/EMBC.2012.6347417
Lu Y, Yang L, Worrell GA, Brinkmann B, Nelson C, He B. Dynamic seizure imaging in patients with extratemporal lobe epilepsy. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2012. p. 6228-6231. 6347417 https://doi.org/10.1109/EMBC.2012.6347417
Lu, Yunfeng ; Yang, Lin ; Worrell, Gregory Alan ; Brinkmann, Benjamin ; Nelson, Cindy ; He, Bin. / Dynamic seizure imaging in patients with extratemporal lobe epilepsy. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2012. pp. 6228-6231
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