TY - GEN
T1 - Dynamic imaging of ictal rhythmic activity using dense-array EEG
AU - Yang, Lin
AU - Wilke, Christopher
AU - Brinkmann, Benjamin
AU - Worrell, Gregory A.
AU - He, Bin
PY - 2011
Y1 - 2011
N2 - Electroencephalogram (EEG) is an important component of the pre-surgical evaluation in the treatment of medically intractable epilepsy. However, clinical EEG uses 19 to 32 electrodes that significantly limits its localization ability. Recent development of dense-array recording techniques has suggested that increased spatial sampling rate improves the accuracy of source localization. In the current study, we proposed a 76-channel EEG system for the long-term monitoring of epilepsy patients, and proposed a dynamic seizure imaging (DSI) technique to image the ictal rhythmic activity that may evolve through time, space and frequency. We tested the system in a cohort of 8 patients and our results show that the DSI estimated the seizure activity in good correlation with intracranial recordings, successful surgery outcomes and other clinical evidence. The proposed dense-array recording and DSI imaging approach enable a non-invasive but quantitative imaging of continuous seizure activity. The results suggest that DSI may potentially be useful to assist the pre-surgical evaluation in patients with intractable epilepsy.
AB - Electroencephalogram (EEG) is an important component of the pre-surgical evaluation in the treatment of medically intractable epilepsy. However, clinical EEG uses 19 to 32 electrodes that significantly limits its localization ability. Recent development of dense-array recording techniques has suggested that increased spatial sampling rate improves the accuracy of source localization. In the current study, we proposed a 76-channel EEG system for the long-term monitoring of epilepsy patients, and proposed a dynamic seizure imaging (DSI) technique to image the ictal rhythmic activity that may evolve through time, space and frequency. We tested the system in a cohort of 8 patients and our results show that the DSI estimated the seizure activity in good correlation with intracranial recordings, successful surgery outcomes and other clinical evidence. The proposed dense-array recording and DSI imaging approach enable a non-invasive but quantitative imaging of continuous seizure activity. The results suggest that DSI may potentially be useful to assist the pre-surgical evaluation in patients with intractable epilepsy.
KW - Dense-array EEG
KW - Dynamic seizure imaging (DSI)
KW - Epilepsy
KW - Pre-surgical planning
UR - http://www.scopus.com/inward/record.url?scp=84055222943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84055222943&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2011.6092039
DO - 10.1109/IEMBS.2011.6092039
M3 - Conference contribution
C2 - 22256263
AN - SCOPUS:84055222943
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 8271
EP - 8274
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -