Dynamic gadolinium-enhanced MR imaging of the spleen: Normal enhancement patterns and evaluation of splenic lesions

S. A. Mirowitz, J. J. Brown, J. K.T. Lee, J. P. Heiken

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The authors studied the ability to improve detection of splenic lesions during suspended respiration with dynamic gadolinium-enhanced T1-weighted spin-echo magnetic resonance (MR) imaging. In the first phase of the study, normal splenic contrast material enhancement patterns were assessed in 10 control patients without splenic lesions. A heterogeneous signal intensity pattern was observed in 11 patients with splenic lesions during bolus injection of gadopentetate dimeglumine, with conversion to homogeneous enhancement 1 minute later. Mean splenic enhancement was 321% during bolus injection, with a rapid return toward baseline signal intensity thereafter. In the second phase, evaluation of 18 splenic lesions detected with contrast-enhanced computed tomography in 11 patients revealed that dynamic gadolinium-enhanced MR pulse sequences significantly improved lesion conspicuity and detectability compared with conventional T1- and T2-weighted pulse sequences. Contrast-to-artifact ratio measurements were 0.5, 3.7, and 9.3 for conventional T1-weighted, T2-weighted, and dynamic gadolinium-enhanced MR images, respectively.

Original languageEnglish (US)
Pages (from-to)681-686
Number of pages6
Issue number3
StatePublished - Jan 1 1991


  • Gadolinium
  • Magnetic resonance (MR), pulse sequences
  • Magnetic resonance (MR), rapid imaging
  • Spleen, MR studies, 775.1214
  • Spleen, cysts, 775.3121
  • Spleen, hemangioma, 775.3194
  • Spleen, lymphoma, 775.34
  • Spleen, neoplasms, 775.3121, 775.3194, 775.332, 775.344

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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