Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers

Troy J. Cross, Justin J. Kavanagh, Toni Breskovic, Bruce David Johnson, Zeljko Dujic

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aims: To examine whether dynamic cerebral autoregulation is acutely impaired during maximal voluntary apnoea in trained divers. Methods: Mean arterial pressure (MAP), cerebral blood flow-velocity (CBFV) and end-tidal partial pressures of O2 and CO2 (PETO2 and PETCO2) were measured in eleven trained, male apnoea divers (28±2 yr; 182±2 cm, 76±7 kg) during maximal "dry" breath holding. Dynamic cerebral autoregulation was assessed by determining the strength of phase synchronisation between MAP and CBFV during maximal apnoea. Results: The strength of phase synchronisation between MAP and CBFV increased from rest until the end of maximal voluntary apnoea (P<0.05), suggesting that dynamic cerebral autoregulation had weakened by the apnoea breakpoint. The magnitude of impairment in dynamic cerebral autoregulation was strongly, and positively related to the rise in PETCO2 observed during maximal breath holding (R2 =0.67, P<0.05). Interestingly, the impairment in dynamic cerebral autoregulation was not related to the fall in PETO 2 induced by apnoea (R2 = 0.01, P= 0.75). Conclusions: This study is the first to report that dynamic cerebral autoregulation is acutely impaired in trained divers performing maximal voluntary apnoea. Furthermore, our data suggest that the impaired autoregulatory response is related to the change in PETCO2, but not PETO2, during maximal apnoea in trained divers.

Original languageEnglish (US)
Article numbere87598
JournalPLoS One
Volume9
Issue number2
DOIs
StatePublished - Feb 3 2014

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autoregulation
apnea
Apnea
Homeostasis
Cerebrovascular Circulation
Flow velocity
Blood Flow Velocity
blood flow
Breath Holding
Arterial Pressure
Synchronization
Blood
strength (mechanics)
Blood pressure
Partial pressure
Partial Pressure

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers. / Cross, Troy J.; Kavanagh, Justin J.; Breskovic, Toni; Johnson, Bruce David; Dujic, Zeljko.

In: PLoS One, Vol. 9, No. 2, e87598, 03.02.2014.

Research output: Contribution to journalArticle

Cross, Troy J. ; Kavanagh, Justin J. ; Breskovic, Toni ; Johnson, Bruce David ; Dujic, Zeljko. / Dynamic cerebral autoregulation is acutely impaired during maximal apnoea in trained divers. In: PLoS One. 2014 ; Vol. 9, No. 2.
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