DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment

Kejal M Kantarci, Ronald Carl Petersen, Bradley F Boeve, David S Knopman, S. D. Weigand, P. C. O'Brien, M. M. Shiung, G. E. Smith, R. J. Ivnik, Eric George Tangalos, Clifford R Jr. Jack

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

The authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to Alzheimer disease (AD) in amnestic mild cognitive impairment (aMCI). Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002). Magnetic resonance diffusion-weighted imaging may help identify patients with aMCI who will progress to AD as well as or better than structural MRI measures of hippocampal atrophy.

Original languageEnglish (US)
Pages (from-to)902-904
Number of pages3
JournalNeurology
Volume64
Issue number5
StatePublished - Mar 8 2005

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Alzheimer Disease
Diffusion Magnetic Resonance Imaging
Atrophy
Water
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment. / Kantarci, Kejal M; Petersen, Ronald Carl; Boeve, Bradley F; Knopman, David S; Weigand, S. D.; O'Brien, P. C.; Shiung, M. M.; Smith, G. E.; Ivnik, R. J.; Tangalos, Eric George; Jack, Clifford R Jr.

In: Neurology, Vol. 64, No. 5, 08.03.2005, p. 902-904.

Research output: Contribution to journalArticle

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