DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment

K. Kantarci, R. C. Petersen, B. F. Boeve, D. S. Knopman, S. D. Weigand, P. C. O'Brien, M. M. Shiung, G. E. Smith, R. J. Ivnik, E. G. Tangalos, C. R. Jack

Research output: Contribution to journalArticle

190 Scopus citations

Abstract

The authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to Alzheimer disease (AD) in amnestic mild cognitive impairment (aMCI). Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002). Magnetic resonance diffusion-weighted imaging may help identify patients with aMCI who will progress to AD as well as or better than structural MRI measures of hippocampal atrophy.

Original languageEnglish (US)
Pages (from-to)902-904
Number of pages3
JournalNeurology
Volume64
Issue number5
DOIs
StatePublished - Mar 8 2005

ASJC Scopus subject areas

  • Clinical Neurology

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