Duration and severity of hypoglycemia needed to induce neuropathy

Sjunji Yasaki, Peter J Dyck

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The duration and severity of hypoglycemia needed to induce neuropathy is not known. To test these variables, the percentage of teased fibers of peroneal and tibial nerves showing graded pathologic abnormalities was estimated in groups of rats that had been made hypoglycemic for various times and severities one week earlier. The techniques used maintained core temperature, pO2, pCO2, and hematocrit within physiologic limits. A control group was anesthetized and mechanically ventilated but insulin was not given. A second control group underwent no experimental manipulation. Life could not be sustained with hypoglycemia below 1 mmol/l. In 23 rats that were hypoglycemic (1.4 ± 0.2 mmol/l, mean ± S.E.M.) for various times less than 11 h, the frequency of axonal degeneration of teased myelinated fibers (0%-1%) was not different than in controls. In 9 young rats that were hypoglycemic (1.4 ± 0.0 mmol/l) for various times of 12 or more hours, the frequency of fiber degeneration was significantly higher than in controls (P < 0.01) and increased to as high as 26%. By contrast, in 5 older rats that were hypoglycemic (1.5 ± 0.1 mol/l) for various times of 12 or more hours, the frequency of degeneration was not different from that of controls. Both duration and severity of hypoglycemia are risk factors for fiber degeneration. The peripheral nerves are more vulnerable to prolonged severe hypoglycemia in younger rats than in older rats.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalBrain Research
Volume531
Issue number1-2
DOIs
StatePublished - Oct 29 1990

Fingerprint

Hypoglycemia
Hypoglycemic Agents
Tibial Nerve
Peroneal Nerve
Control Groups
Peripheral Nerves
Hematocrit
Insulin
Temperature

Keywords

  • Axon
  • Fiber degeneration
  • Hypoglycemic neuropathy
  • Insulin
  • Peripheral nerve
  • Rat

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Duration and severity of hypoglycemia needed to induce neuropathy. / Yasaki, Sjunji; Dyck, Peter J.

In: Brain Research, Vol. 531, No. 1-2, 29.10.1990, p. 8-15.

Research output: Contribution to journalArticle

@article{5cb50718cd204b9b89511910163186f4,
title = "Duration and severity of hypoglycemia needed to induce neuropathy",
abstract = "The duration and severity of hypoglycemia needed to induce neuropathy is not known. To test these variables, the percentage of teased fibers of peroneal and tibial nerves showing graded pathologic abnormalities was estimated in groups of rats that had been made hypoglycemic for various times and severities one week earlier. The techniques used maintained core temperature, pO2, pCO2, and hematocrit within physiologic limits. A control group was anesthetized and mechanically ventilated but insulin was not given. A second control group underwent no experimental manipulation. Life could not be sustained with hypoglycemia below 1 mmol/l. In 23 rats that were hypoglycemic (1.4 ± 0.2 mmol/l, mean ± S.E.M.) for various times less than 11 h, the frequency of axonal degeneration of teased myelinated fibers (0{\%}-1{\%}) was not different than in controls. In 9 young rats that were hypoglycemic (1.4 ± 0.0 mmol/l) for various times of 12 or more hours, the frequency of fiber degeneration was significantly higher than in controls (P < 0.01) and increased to as high as 26{\%}. By contrast, in 5 older rats that were hypoglycemic (1.5 ± 0.1 mol/l) for various times of 12 or more hours, the frequency of degeneration was not different from that of controls. Both duration and severity of hypoglycemia are risk factors for fiber degeneration. The peripheral nerves are more vulnerable to prolonged severe hypoglycemia in younger rats than in older rats.",
keywords = "Axon, Fiber degeneration, Hypoglycemic neuropathy, Insulin, Peripheral nerve, Rat",
author = "Sjunji Yasaki and Dyck, {Peter J}",
year = "1990",
month = "10",
day = "29",
doi = "10.1016/0006-8993(90)90752-W",
language = "English (US)",
volume = "531",
pages = "8--15",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Duration and severity of hypoglycemia needed to induce neuropathy

AU - Yasaki, Sjunji

AU - Dyck, Peter J

PY - 1990/10/29

Y1 - 1990/10/29

N2 - The duration and severity of hypoglycemia needed to induce neuropathy is not known. To test these variables, the percentage of teased fibers of peroneal and tibial nerves showing graded pathologic abnormalities was estimated in groups of rats that had been made hypoglycemic for various times and severities one week earlier. The techniques used maintained core temperature, pO2, pCO2, and hematocrit within physiologic limits. A control group was anesthetized and mechanically ventilated but insulin was not given. A second control group underwent no experimental manipulation. Life could not be sustained with hypoglycemia below 1 mmol/l. In 23 rats that were hypoglycemic (1.4 ± 0.2 mmol/l, mean ± S.E.M.) for various times less than 11 h, the frequency of axonal degeneration of teased myelinated fibers (0%-1%) was not different than in controls. In 9 young rats that were hypoglycemic (1.4 ± 0.0 mmol/l) for various times of 12 or more hours, the frequency of fiber degeneration was significantly higher than in controls (P < 0.01) and increased to as high as 26%. By contrast, in 5 older rats that were hypoglycemic (1.5 ± 0.1 mol/l) for various times of 12 or more hours, the frequency of degeneration was not different from that of controls. Both duration and severity of hypoglycemia are risk factors for fiber degeneration. The peripheral nerves are more vulnerable to prolonged severe hypoglycemia in younger rats than in older rats.

AB - The duration and severity of hypoglycemia needed to induce neuropathy is not known. To test these variables, the percentage of teased fibers of peroneal and tibial nerves showing graded pathologic abnormalities was estimated in groups of rats that had been made hypoglycemic for various times and severities one week earlier. The techniques used maintained core temperature, pO2, pCO2, and hematocrit within physiologic limits. A control group was anesthetized and mechanically ventilated but insulin was not given. A second control group underwent no experimental manipulation. Life could not be sustained with hypoglycemia below 1 mmol/l. In 23 rats that were hypoglycemic (1.4 ± 0.2 mmol/l, mean ± S.E.M.) for various times less than 11 h, the frequency of axonal degeneration of teased myelinated fibers (0%-1%) was not different than in controls. In 9 young rats that were hypoglycemic (1.4 ± 0.0 mmol/l) for various times of 12 or more hours, the frequency of fiber degeneration was significantly higher than in controls (P < 0.01) and increased to as high as 26%. By contrast, in 5 older rats that were hypoglycemic (1.5 ± 0.1 mol/l) for various times of 12 or more hours, the frequency of degeneration was not different from that of controls. Both duration and severity of hypoglycemia are risk factors for fiber degeneration. The peripheral nerves are more vulnerable to prolonged severe hypoglycemia in younger rats than in older rats.

KW - Axon

KW - Fiber degeneration

KW - Hypoglycemic neuropathy

KW - Insulin

KW - Peripheral nerve

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0025106953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025106953&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(90)90752-W

DO - 10.1016/0006-8993(90)90752-W

M3 - Article

C2 - 2126974

AN - SCOPUS:0025106953

VL - 531

SP - 8

EP - 15

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -