Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade

Gerold J. Wetscher, Ronald A. Hinder, David Kretchmar, Ronald Stinson, Galen Perdikis, Thomas Christopher Smyrk, Paul J. Klingler, Thomas E. Adrian

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We investigated whether duodenogastric reflux (DGR) together with gastroesophageal reflux causes growth stimulation of the foregut mucosa and if additional gastric acid suppression enhances the effect of DGR. DGR was induced in rats using a split gastroenterostomy. A cardiomyotomy was performed across the gastroeophageal junction in order to enhance reflux into the esophagus. DGR rats were divided into six subgroups: DGR, DGR + truncal vagotomy, DGR + omeprazole, DGR + gastrin receptor blockade, DGR + omeprazole + gastrin receptor blockade, and DGR + gastrin. Two sham groups, one with and one without omeprazole treatment, served as controls. DGR significantly increased the weight and DNA content of the esophageal and gastric mucosa, which was further enhanced by vagotomy or omeprazole. Histology revealed foveolar hyperplasia in the stomach and esophageal mucosal hyperplasia in these groups. In addition, severe esophagitis was found in the DGR group receiving omeprazole. Omeprazole without DGR had no growth-stimulating effect on the foregut mucosa. DGR-induced growth stimulation was accompanied by hypergastrinemia. Increased growth in the stomach but not the esophagus was inhibited by gastrin receptor blockade. Gastrin administration did not result in enhancement of DGR-induced growth stimulation of the foregut mucosa. It is concluded that DGR, often present in severe reflux esophagitis, causes mucosal growth of the foregut of rats. This trophic response may explain why severe reflux esophagitis is associated with an increased risk of esophageal adenocarcinoma. DGR-induced growth stimulation of the foregut is potentiated by gastric acid suppression, suggesting that chronic antisecretory medication in gastroesophageal reflux may not always be advisable. Omeprazole + DGR caused severe esophageal damage, which may explain why antisecretory medication may fail to heal severe reflux esophagitis.

Original languageEnglish (US)
Pages (from-to)2166-2173
Number of pages8
JournalDigestive Diseases and Sciences
Volume41
Issue number11
StatePublished - 1996
Externally publishedYes

Fingerprint

Duodenogastric Reflux
Gastric Acid
Mucous Membrane
Growth
Omeprazole
Cholecystokinin B Receptor
Peptic Esophagitis
Gastrins
Gastroesophageal Reflux
Esophagus
Hyperplasia
Stomach
Truncal Vagotomy
Gastroenterostomy

Keywords

  • Complications
  • Duodenogastric reflux
  • Growth stimulation
  • Reflux esophagitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Wetscher, G. J., Hinder, R. A., Kretchmar, D., Stinson, R., Perdikis, G., Smyrk, T. C., ... Adrian, T. E. (1996). Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade. Digestive Diseases and Sciences, 41(11), 2166-2173.

Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade. / Wetscher, Gerold J.; Hinder, Ronald A.; Kretchmar, David; Stinson, Ronald; Perdikis, Galen; Smyrk, Thomas Christopher; Klingler, Paul J.; Adrian, Thomas E.

In: Digestive Diseases and Sciences, Vol. 41, No. 11, 1996, p. 2166-2173.

Research output: Contribution to journalArticle

Wetscher, GJ, Hinder, RA, Kretchmar, D, Stinson, R, Perdikis, G, Smyrk, TC, Klingler, PJ & Adrian, TE 1996, 'Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade', Digestive Diseases and Sciences, vol. 41, no. 11, pp. 2166-2173.
Wetscher GJ, Hinder RA, Kretchmar D, Stinson R, Perdikis G, Smyrk TC et al. Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade. Digestive Diseases and Sciences. 1996;41(11):2166-2173.
Wetscher, Gerold J. ; Hinder, Ronald A. ; Kretchmar, David ; Stinson, Ronald ; Perdikis, Galen ; Smyrk, Thomas Christopher ; Klingler, Paul J. ; Adrian, Thomas E. / Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade. In: Digestive Diseases and Sciences. 1996 ; Vol. 41, No. 11. pp. 2166-2173.
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