Duchenne dystrophy: Ultrastructural localization of the acetylcholine receptor and intracellular microelectrode studies of neuromuscular transmission

Hiroyoshi Sakakibara, Andrew G. Engel, Edward H. Lambert

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Despite focal degeneration and simplification of the postsynaptic region in Duchenne dystrophy, the postsynaptic acetylcholine receptor (AChR) is preserved. This is in contrast to myasthenia gravis where similar postsynaptic alterations are invariably associated with a marked decrease in AChR. There is no extrajunctional spread of AChR in Duchenne dystrophy. The amplitude and frequency of miniature end-plate potentials and the number of transmitter quanta released by nerve impulse are normal but the resting membrane potential is lower than normal. The findings indicate that the release and the postsynaptic responsiveness to acetylcholine are intact in Duchenne dystrophy.

Original languageEnglish (US)
Pages (from-to)741-745
Number of pages5
JournalNeurology
Volume27
Issue number8
StatePublished - Aug 1977

ASJC Scopus subject areas

  • Clinical Neurology

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