Duchenne dystrophy. I. Morphometric study of the muscle microvasculature

F. Jerusalem, Andrew G Engel, M. R. Gomez

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The fine structure of 71 capillaries from 9 cases of Duchenne dystrophy and of 30 capillaries from 5 normal children were analyzed morphometrically. The mean capillary size is significantly increased in Duchenne dystrophy. The concentration of pinocytotic vesicles per unit endothelial area is slightly but significantly reduced in the disease. The mean muscle fiber area served per capillary is essentially normal in Duchenne dystrophy. 66% of the capillaries in Duchenne dystrophy and 3% of the capillaries in normal children had replicated basal lamina. The same abnormality was also observed in polymyositis, dermatomyositis and scleroderma at frequencies comparable to that in Duchenne dystrophy; and in systemic lupus erythematosus, infantile and childhood spinal muscular atrophy and in other types of dystrophies at significantly lower frequencies than in Duchenne dystrophy. The cause and significance of the basement membrane alteration in Duchenne dystrophy is not yet established. Platelet thrombi, occluded blood vessels, and endothelial cell necrosis were not observed in Duchenne dystrophy. The morphological findings provide no adequate evidence that Duchenne dystrophy is caused by a primary abnormality of the muscle microcirculation.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalBrain
Volume97
Issue number1
StatePublished - 1974

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Microvessels
Muscle
scleroderma (skin disease)
dermatomyositis
polymyositis
Microcirculation
lupus erythematosus
Muscles
muscles
muscular atrophy
laminae (animals)
Endothelial cells
basement membrane
Blood vessels
Platelets
blood vessels
childhood
muscle fibers
endothelial cells
necrosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Duchenne dystrophy. I. Morphometric study of the muscle microvasculature. / Jerusalem, F.; Engel, Andrew G; Gomez, M. R.

In: Brain, Vol. 97, No. 1, 1974, p. 115-122.

Research output: Contribution to journalArticle

Jerusalem, F, Engel, AG & Gomez, MR 1974, 'Duchenne dystrophy. I. Morphometric study of the muscle microvasculature', Brain, vol. 97, no. 1, pp. 115-122.
Jerusalem, F. ; Engel, Andrew G ; Gomez, M. R. / Duchenne dystrophy. I. Morphometric study of the muscle microvasculature. In: Brain. 1974 ; Vol. 97, No. 1. pp. 115-122.
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