Dual secretagogue drive of burst-like growth hormone secretion in postmenopausal compared with premenopausal women studied under an experimental estradiol clamp

Dana Erickson, Daniel M. Keenan, Kristi Mielke, Kandace Bradford, Cyril Y. Bowers, John M. Miles, Johannes D. Veldhuis

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We show that in an experimentally enforced estradiol-predominant milieu, postmenopausal compared with premenopausal women maintain 1) decreased fasting GH and IGF-I concentrations, 2) reduced basal and pulsatile GH secretion, and 3) attenuated GH secretion after maximal stimulation by the paired secretagogues L-arginine/GH-releasing peptide (GHRP)-2, L-arginine/GHRH, and GHRP-2/GHRH. These foregoing outcomes are selective, because menopausal status did not determine mean GH secretory-burst frequency or peptide-induced waveform shortening. Abdominal visceral fat mass predicted up to 25% of the variability in fasting and stimulated GH secretion in the combined cohorts under fixed systemic estradiol availability. Accordingly, as much as three-fourths of interindividual differences in burst-like GH secretion among healthy pre- and postmenopausal women arise from age-related mechanisms independently of short-term systemic estrogen availability and relative intraabdominal adiposity.

Original languageEnglish (US)
Pages (from-to)4746-4754
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number9
DOIs
StatePublished - Sep 1 2004

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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