TY - JOUR
T1 - Dual Primary IGH Translocations in Multiple Myeloma
T2 - A Novel Finding
AU - Ravindran, Aishwarya
AU - Greipp, Patricia T.
AU - Wongchaowart, Nicholas
AU - Smadbeck, James B.
AU - Peterson, Jess F.
AU - Ketterling, Rhett P.
AU - Kumar, Shaji K.
AU - Baughn, Linda B.
N1 - Publisher Copyright:
© 2021
PY - 2021/9
Y1 - 2021/9
N2 - • Cytogenetics in multiple myeloma is utilized to risk stratify patients into standard and high-risk groups. • Immunoglobulin heavy chain (IGH) gene translocations such as t(4;14) and t(14;16) are high-risk cytogenetic abnormalities that confer poor outcomes to therapy in multiple myeloma. • Primary IGH translocations are typically considered mutually exclusive events. • Here, we describe a case of multiple myeloma with dual primary IGH translocations involving both t(4;14) and t(14;16).
AB - • Cytogenetics in multiple myeloma is utilized to risk stratify patients into standard and high-risk groups. • Immunoglobulin heavy chain (IGH) gene translocations such as t(4;14) and t(14;16) are high-risk cytogenetic abnormalities that confer poor outcomes to therapy in multiple myeloma. • Primary IGH translocations are typically considered mutually exclusive events. • Here, we describe a case of multiple myeloma with dual primary IGH translocations involving both t(4;14) and t(14;16).
KW - Clonal Cytogenetic Abnormality
KW - Cytogenetics Risk Stratification
KW - Immunoglobulin heavy chain
KW - Plasma Cell Neoplasm
KW - Plasma Cell-Specific FISH
UR - http://www.scopus.com/inward/record.url?scp=85108582171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108582171&partnerID=8YFLogxK
U2 - 10.1016/j.clml.2021.05.001
DO - 10.1016/j.clml.2021.05.001
M3 - Article
C2 - 34172422
AN - SCOPUS:85108582171
SN - 2152-2650
VL - 21
SP - e710-e713
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 9
ER -