Dual Primary IGH Translocations in Multiple Myeloma: A Novel Finding

Aishwarya Ravindran; Patricia T. Greipp; Nicholas Wongchaowart; James B. Smadbeck; Jess F. Peterson; Rhett P. Ketterling; Shaji K. Kumar; Linda B. Baughn

doi:10.1016/j.clml.2021.05.001

Dual Primary IGH Translocations in Multiple Myeloma: A Novel Finding

Aishwarya Ravindran, Patricia T. Greipp, Nicholas Wongchaowart, James B. Smadbeck, Jess F. Peterson, Rhett P. Ketterling, Shaji K. Kumar, Linda B. Baughn

Research output: Contribution to journal › Article › peer-review

Abstract

• Cytogenetics in multiple myeloma is utilized to risk stratify patients into standard and high-risk groups. • Immunoglobulin heavy chain (IGH) gene translocations such as t(4;14) and t(14;16) are high-risk cytogenetic abnormalities that confer poor outcomes to therapy in multiple myeloma. • Primary IGH translocations are typically considered mutually exclusive events. • Here, we describe a case of multiple myeloma with dual primary IGH translocations involving both t(4;14) and t(14;16).

Original language	English (US)
Pages (from-to)	e710-e713
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	21
Issue number	9
DOIs	https://doi.org/10.1016/j.clml.2021.05.001
State	Published - Sep 2021

Keywords

Clonal Cytogenetic Abnormality
Cytogenetics Risk Stratification
Immunoglobulin heavy chain
Plasma Cell Neoplasm
Plasma Cell-Specific FISH

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.clml.2021.05.001

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@article{284567440e6148c08cc51a478563b680,

title = "Dual Primary IGH Translocations in Multiple Myeloma: A Novel Finding",

abstract = "• Cytogenetics in multiple myeloma is utilized to risk stratify patients into standard and high-risk groups. • Immunoglobulin heavy chain (IGH) gene translocations such as t(4;14) and t(14;16) are high-risk cytogenetic abnormalities that confer poor outcomes to therapy in multiple myeloma. • Primary IGH translocations are typically considered mutually exclusive events. • Here, we describe a case of multiple myeloma with dual primary IGH translocations involving both t(4;14) and t(14;16).",

keywords = "Clonal Cytogenetic Abnormality, Cytogenetics Risk Stratification, Immunoglobulin heavy chain, Plasma Cell Neoplasm, Plasma Cell-Specific FISH",

author = "Aishwarya Ravindran and Greipp, {Patricia T.} and Nicholas Wongchaowart and Smadbeck, {James B.} and Peterson, {Jess F.} and Ketterling, {Rhett P.} and Kumar, {Shaji K.} and Baughn, {Linda B.}",

note = "Funding Information: The authors thank the cytotechnologists (Sara M. Kloft-Nelson, Ryan A. Knudson, and Troy J. Gliem) at the Mayo Clinic Cytogenetics Core, Medical Genome Facility, who assisted in performing the FISH studies relevant to this study. The Cytogenetics Core is supported by the Mayo Clinic Comprehensive Cancer Center Grant (P30CA15083). Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = sep,

doi = "10.1016/j.clml.2021.05.001",

language = "English (US)",

volume = "21",

pages = "e710--e713",

journal = "Clinical Lymphoma",

issn = "2152-2669",

publisher = "Cancer Media Group",

number = "9",

}

TY - JOUR

T1 - Dual Primary IGH Translocations in Multiple Myeloma

T2 - A Novel Finding

AU - Ravindran, Aishwarya

AU - Greipp, Patricia T.

AU - Wongchaowart, Nicholas

AU - Smadbeck, James B.

AU - Peterson, Jess F.

AU - Ketterling, Rhett P.

AU - Kumar, Shaji K.

AU - Baughn, Linda B.

N1 - Funding Information: The authors thank the cytotechnologists (Sara M. Kloft-Nelson, Ryan A. Knudson, and Troy J. Gliem) at the Mayo Clinic Cytogenetics Core, Medical Genome Facility, who assisted in performing the FISH studies relevant to this study. The Cytogenetics Core is supported by the Mayo Clinic Comprehensive Cancer Center Grant (P30CA15083). Publisher Copyright: © 2021

PY - 2021/9

Y1 - 2021/9

N2 - • Cytogenetics in multiple myeloma is utilized to risk stratify patients into standard and high-risk groups. • Immunoglobulin heavy chain (IGH) gene translocations such as t(4;14) and t(14;16) are high-risk cytogenetic abnormalities that confer poor outcomes to therapy in multiple myeloma. • Primary IGH translocations are typically considered mutually exclusive events. • Here, we describe a case of multiple myeloma with dual primary IGH translocations involving both t(4;14) and t(14;16).

AB - • Cytogenetics in multiple myeloma is utilized to risk stratify patients into standard and high-risk groups. • Immunoglobulin heavy chain (IGH) gene translocations such as t(4;14) and t(14;16) are high-risk cytogenetic abnormalities that confer poor outcomes to therapy in multiple myeloma. • Primary IGH translocations are typically considered mutually exclusive events. • Here, we describe a case of multiple myeloma with dual primary IGH translocations involving both t(4;14) and t(14;16).

KW - Clonal Cytogenetic Abnormality

KW - Cytogenetics Risk Stratification

KW - Immunoglobulin heavy chain

KW - Plasma Cell Neoplasm

KW - Plasma Cell-Specific FISH

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UR - http://www.scopus.com/inward/citedby.url?scp=85108582171&partnerID=8YFLogxK

U2 - 10.1016/j.clml.2021.05.001

DO - 10.1016/j.clml.2021.05.001

M3 - Article

C2 - 34172422

AN - SCOPUS:85108582171

VL - 21

SP - e710-e713

JO - Clinical Lymphoma

JF - Clinical Lymphoma

SN - 2152-2669

IS - 9

ER -

Dual Primary IGH Translocations in Multiple Myeloma: A Novel Finding

Abstract

Keywords

ASJC Scopus subject areas

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