DTI analyses and clinical applications in Alzheimers Disease

Kenichi Oishi, Michelle M Mielke, Marilyn Albert, Constantine G. Lyketsos, Susumu Mori

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

DTI is one of the most effective MR tools for the investigation of the brain anatomy. In addition to the gray matter, histopathological studies indicate that white matter is also a good target for both the early diagnosis of AD and for monitoring disease progression, which motivates us to use DTI to study AD patients in vivo. There are already a large amount of studies reporting significant differences between AD patients and controls, as well as to predict progression of disease in symptomatic non-demented individuals. Application of these findings in clinical practice remains to be demonstrated.

Original languageEnglish (US)
Pages (from-to)287-296
Number of pages10
JournalJournal of Alzheimer's Disease
Volume26
Issue numberSUPPL. 3
DOIs
StatePublished - 2011
Externally publishedYes

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Keywords

  • Alzheimers disease
  • clinical application
  • diffusion tensor imaging
  • mild cognitive impairment
  • white matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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