Drug treatment of hypertension in pregnancy

Catherine M. Brown, Vesna D. Garovic

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Hypertensive disorders represent major causes of pregnancy-related maternal mortality worldwide. Similar to the non-pregnant population, hypertension is the most common medical disorder encountered during pregnancy and is estimated to occur in about 6-8 % of pregnancies. A recent report highlighted hypertensive disorders as one of the major causes of pregnancy-related maternal deaths in the USA, accounting for 579 (12.3 %) of the 4,693 maternal deaths that occurred between 1998 and 2005. In low-income and middle-income countries, preeclampsia and its convulsive form, eclampsia, are associated with 10-15 % of direct maternal deaths. The optimal timing and choice of therapy for hypertensive pregnancy disorders involves carefully weighing the risk-versus-benefit ratio for each individual patient, with an overall goal of improving maternal and fetal outcomes. In this review, we have compared and contrasted the recommendations from different treatment guidelines and outlined some newer perspectives on management. We aim to provide a clinically oriented guide to the drug treatment of hypertension in pregnancy.

Original languageEnglish (US)
Pages (from-to)283-296
Number of pages14
JournalDrugs
Volume74
Issue number3
DOIs
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Pharmacology (medical)

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