Abstract
The aim of this study was to examine drug prescribing trends for patients with rheumatoid arthritis (RA) over recent years and compare them to matched non-RA subjects. Retrospective prescription data were examined from 2005 to 2014 in a population-based incidence cohort of patients with RA and comparable non-RA subjects. Drugs for or related to the treatment of RA were excluded. Comparisons between cohorts of percentages of patients with at least one prescription in a specific drug category/class were performed using Poisson regression models adjusted for age and sex. The study included 497 RA (71 % female) and 527 non-RA subjects (70 % female). The overall observed percentage of subjects who were prescribed at least one drug over the 10-year period was somewhat higher among the RA compared to non-RA subjects (relative risk [RR], 1.04; 95 % confidence interval [CI], 0.99, 1.08). Over the study period, both groups demonstrated significant increases in the percentages of patients with at least one prescription (age- and sex-adjusted 7 % increase over 10 years in RA, p < 0.001; 11 % increase in non-RA, p < 0.001). Drugs that were more common among RA than non-RA included gastrointestinal drugs, antimicrobials, calcium metabolism modifiers, thyroid hormone replacement therapy, tricyclic antidepressants, antiasthma/inhaled corticosteroids, proton pump inhibitors, contraceptives, antihypertensives, and some others. Prescription drugs that were less common in RA than non-RA were statins and other antilipemic drugs. Excluding drug prescriptions specifically for treatment of RA, there was a marked overall increase in prescriptions for drugs for both RA and non-RA cohorts over the study period.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| Journal | Clinical Rheumatology |
| DOIs | |
| State | Accepted/In press - Jun 22 2016 |
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Keywords
- Drug use
- Prescription patterns
- Rheumatoid arthritis
- Statins
ASJC Scopus subject areas
- Rheumatology
Cite this
Drug prescribing trends in adults with rheumatoid arthritis : a population-based comparative study from 2005 to 2014. / Zamora-Legoff, Jorge A.; Myasoedova, Elena; Matteson, Eric Lawrence; Achenbach, Sara J.; Crowson, Cynthia.
In: Clinical Rheumatology, 22.06.2016, p. 1-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Drug prescribing trends in adults with rheumatoid arthritis
T2 - a population-based comparative study from 2005 to 2014
AU - Zamora-Legoff, Jorge A.
AU - Myasoedova, Elena
AU - Matteson, Eric Lawrence
AU - Achenbach, Sara J.
AU - Crowson, Cynthia
PY - 2016/6/22
Y1 - 2016/6/22
N2 - The aim of this study was to examine drug prescribing trends for patients with rheumatoid arthritis (RA) over recent years and compare them to matched non-RA subjects. Retrospective prescription data were examined from 2005 to 2014 in a population-based incidence cohort of patients with RA and comparable non-RA subjects. Drugs for or related to the treatment of RA were excluded. Comparisons between cohorts of percentages of patients with at least one prescription in a specific drug category/class were performed using Poisson regression models adjusted for age and sex. The study included 497 RA (71 % female) and 527 non-RA subjects (70 % female). The overall observed percentage of subjects who were prescribed at least one drug over the 10-year period was somewhat higher among the RA compared to non-RA subjects (relative risk [RR], 1.04; 95 % confidence interval [CI], 0.99, 1.08). Over the study period, both groups demonstrated significant increases in the percentages of patients with at least one prescription (age- and sex-adjusted 7 % increase over 10 years in RA, p < 0.001; 11 % increase in non-RA, p < 0.001). Drugs that were more common among RA than non-RA included gastrointestinal drugs, antimicrobials, calcium metabolism modifiers, thyroid hormone replacement therapy, tricyclic antidepressants, antiasthma/inhaled corticosteroids, proton pump inhibitors, contraceptives, antihypertensives, and some others. Prescription drugs that were less common in RA than non-RA were statins and other antilipemic drugs. Excluding drug prescriptions specifically for treatment of RA, there was a marked overall increase in prescriptions for drugs for both RA and non-RA cohorts over the study period.
AB - The aim of this study was to examine drug prescribing trends for patients with rheumatoid arthritis (RA) over recent years and compare them to matched non-RA subjects. Retrospective prescription data were examined from 2005 to 2014 in a population-based incidence cohort of patients with RA and comparable non-RA subjects. Drugs for or related to the treatment of RA were excluded. Comparisons between cohorts of percentages of patients with at least one prescription in a specific drug category/class were performed using Poisson regression models adjusted for age and sex. The study included 497 RA (71 % female) and 527 non-RA subjects (70 % female). The overall observed percentage of subjects who were prescribed at least one drug over the 10-year period was somewhat higher among the RA compared to non-RA subjects (relative risk [RR], 1.04; 95 % confidence interval [CI], 0.99, 1.08). Over the study period, both groups demonstrated significant increases in the percentages of patients with at least one prescription (age- and sex-adjusted 7 % increase over 10 years in RA, p < 0.001; 11 % increase in non-RA, p < 0.001). Drugs that were more common among RA than non-RA included gastrointestinal drugs, antimicrobials, calcium metabolism modifiers, thyroid hormone replacement therapy, tricyclic antidepressants, antiasthma/inhaled corticosteroids, proton pump inhibitors, contraceptives, antihypertensives, and some others. Prescription drugs that were less common in RA than non-RA were statins and other antilipemic drugs. Excluding drug prescriptions specifically for treatment of RA, there was a marked overall increase in prescriptions for drugs for both RA and non-RA cohorts over the study period.
KW - Drug use
KW - Prescription patterns
KW - Rheumatoid arthritis
KW - Statins
UR - http://www.scopus.com/inward/record.url?scp=84975450787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975450787&partnerID=8YFLogxK
U2 - 10.1007/s10067-016-3335-5
DO - 10.1007/s10067-016-3335-5
M3 - Article
C2 - 27334113
AN - SCOPUS:84975450787
SP - 1
EP - 10
JO - Clinical Rheumatology
JF - Clinical Rheumatology
SN - 0770-3198
ER -