Drug prescribing trends in adults with rheumatoid arthritis: a population-based comparative study from 2005 to 2014

Jorge A. Zamora-Legoff, Elena Myasoedova, Eric L. Matteson, Sara J. Achenbach, Cynthia S. Crowson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The aim of this study was to examine drug prescribing trends for patients with rheumatoid arthritis (RA) over recent years and compare them to matched non-RA subjects. Retrospective prescription data were examined from 2005 to 2014 in a population-based incidence cohort of patients with RA and comparable non-RA subjects. Drugs for or related to the treatment of RA were excluded. Comparisons between cohorts of percentages of patients with at least one prescription in a specific drug category/class were performed using Poisson regression models adjusted for age and sex. The study included 497 RA (71 % female) and 527 non-RA subjects (70 % female). The overall observed percentage of subjects who were prescribed at least one drug over the 10-year period was somewhat higher among the RA compared to non-RA subjects (relative risk [RR], 1.04; 95 % confidence interval [CI], 0.99, 1.08). Over the study period, both groups demonstrated significant increases in the percentages of patients with at least one prescription (age- and sex-adjusted 7 % increase over 10 years in RA, p < 0.001; 11 % increase in non-RA, p < 0.001). Drugs that were more common among RA than non-RA included gastrointestinal drugs, antimicrobials, calcium metabolism modifiers, thyroid hormone replacement therapy, tricyclic antidepressants, antiasthma/inhaled corticosteroids, proton pump inhibitors, contraceptives, antihypertensives, and some others. Prescription drugs that were less common in RA than non-RA were statins and other antilipemic drugs. Excluding drug prescriptions specifically for treatment of RA, there was a marked overall increase in prescriptions for drugs for both RA and non-RA cohorts over the study period.

Original languageEnglish (US)
Pages (from-to)2427-2436
Number of pages10
JournalClinical rheumatology
Volume35
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • Drug use
  • Prescription patterns
  • Rheumatoid arthritis
  • Statins

ASJC Scopus subject areas

  • Rheumatology

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