Drug-Induced Mesovarial Leiomyomas in the Rat–A Review and Additional Data

W. A. Kelly, Ronald J Marler, J. H. Weikel

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Abstract

Leiomyomas developed in the ovarian suspensory ligament (costo-uterine muscle) of rats after long-term treatment with several beta2-adrenoceptor stimulant drugs. The response was evidently related to excessive adrenergic stimulation of a tissue with a high density of ä2-receptors; was inhibited by ä blockade; and was directly related to in vitro pharmacologic potency. Tumor development was dependent on continuous administration of adequate dosages to a susceptible strain of rat. Histologically, all tumors were benign and none were malignant. After many years of clinical experience, there are no known reports of this response in human patients receiving ä2-adrenoceptor-stimulant drugs.

Original languageEnglish (US)
Pages (from-to)13-22
Number of pages10
JournalInternational Journal of Toxicology
Volume12
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Toxicology

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