Drug-Induced Mesovarial Leiomyomas in the Rat–A Review and Additional Data

W. A. Kelly, Ronald J Marler, J. H. Weikel

Research output: Contribution to journalArticle

Abstract

Leiomyomas developed in the ovarian suspensory ligament (costo-uterine muscle) of rats after long-term treatment with several beta2-adrenoceptor stimulant drugs. The response was evidently related to excessive adrenergic stimulation of a tissue with a high density of ä2-receptors; was inhibited by ä blockade; and was directly related to in vitro pharmacologic potency. Tumor development was dependent on continuous administration of adequate dosages to a susceptible strain of rat. Histologically, all tumors were benign and none were malignant. After many years of clinical experience, there are no known reports of this response in human patients receiving ä2-adrenoceptor-stimulant drugs.

Original languageEnglish (US)
Pages (from-to)13-22
Number of pages10
JournalInternational Journal of Toxicology
Volume12
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

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Leiomyoma
Adrenergic Receptors
Rats
Tumors
Myometrium
Ligaments
Pharmaceutical Preparations
Adrenergic Agents
Muscle
Neoplasms
Tissue
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Toxicology

Cite this

Drug-Induced Mesovarial Leiomyomas in the Rat–A Review and Additional Data. / Kelly, W. A.; Marler, Ronald J; Weikel, J. H.

In: International Journal of Toxicology, Vol. 12, No. 1, 1993, p. 13-22.

Research output: Contribution to journalArticle

Kelly, W. A. ; Marler, Ronald J ; Weikel, J. H. / Drug-Induced Mesovarial Leiomyomas in the Rat–A Review and Additional Data. In: International Journal of Toxicology. 1993 ; Vol. 12, No. 1. pp. 13-22.
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