Drug-induced lung disease

Keys to diagnosis and management

Scan G. Barry, Lewis J. Wesselius

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Drug-induced lung disease is often a difficult diagnostic challenge for the clinician because of its diverse presentations and the increasing number of causative agents. Common clinical presentations include interstitial pneumonitis/fibrosis, hypersensitivity pneumonitis, noncardiogenic pulmonary edema, and airways dysfunction. The chest radiograph may not detect early drug-induced lung disease, and radiographic changes in more advanced disease are not specific. Pulmonary function studies, including measurement of diffusing capacity, are more sensitive in detecting early drug-induced lung disease; however, specificity is low. Additional chest imaging techniques, including high-resolution CT scans and gallium scans, can increase diagnostic accuracy. Bronchoscopy has limited diagnostic utility for these disorders, although it can exclude other possible diagnoses such as infection or alveolar hemorrhage. Thoracoscopic lung biopsy is a promising alternative to standard open lung biopsy. Therapy must be individualized and includes discontinuation of the offending drug, supportive care, and use of corticosteroids in patients with severe symptoms or lung dysfunction.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalClinical Pulmonary Medicine
Volume3
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

Lung Diseases
Lung
Pharmaceutical Preparations
Thorax
Extrinsic Allergic Alveolitis
Biopsy
Gallium
Interstitial Lung Diseases
Bronchoscopy
Pulmonary Edema
Adrenal Cortex Hormones
Fibrosis
Hemorrhage
Infection
Therapeutics

Keywords

  • Drug toxicity
  • Pneumonitis
  • Pulmonary edema
  • Pulmonary fibrosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Barry, S. G., & Wesselius, L. J. (1996). Drug-induced lung disease: Keys to diagnosis and management. Clinical Pulmonary Medicine, 3(3), 157-163.

Drug-induced lung disease : Keys to diagnosis and management. / Barry, Scan G.; Wesselius, Lewis J.

In: Clinical Pulmonary Medicine, Vol. 3, No. 3, 1996, p. 157-163.

Research output: Contribution to journalArticle

Barry, SG & Wesselius, LJ 1996, 'Drug-induced lung disease: Keys to diagnosis and management', Clinical Pulmonary Medicine, vol. 3, no. 3, pp. 157-163.
Barry, Scan G. ; Wesselius, Lewis J. / Drug-induced lung disease : Keys to diagnosis and management. In: Clinical Pulmonary Medicine. 1996 ; Vol. 3, No. 3. pp. 157-163.
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