Drug-induced lung disease: A pragmatic classification incorporating HRCT appearances

Jeffrey L. Myers, Andrew H. Limper, Stephen J. Swensen

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Drug-induced lung disease frequently poses a diagnostic challenge. Knowledge of common radiological patterns of lung involvement and corresponding histopathologic diagnoses can facilitate management of individual patients. We outline a framework for understanding radiological and histologic patterns of drug-induced lung disease. Diffuse forms of drug-induced lung disease include processes that mimic acute respiratory distress syndrome (ARDS) and diffuse alveolar hemorrhage. These patterns of drug-induced lung disease are especially common in patients receiving cytotoxic chemotherapeutic agents. Chronic forms of drug-induced lung disease include many of the interstitial pneumonias seen more commonly in patients with idiopathic disease. Bronchiolitis obliterans organizing pneumonia and eosinophilic pneumonia are nonspecific patterns of drug-induced lung disease that are radiologically and histologically indistinguishable from their idiopathic counterparts. In some patients organizing pneumonia and eosinophilic pneumonia mimic the radiological appearance of neoplastic disease.

Original languageEnglish (US)
Pages (from-to)445-453
Number of pages9
JournalSeminars in Respiratory and Critical Care Medicine
Volume24
Issue number4
DOIs
StatePublished - Aug 1 2003

Keywords

  • Bronchiolitis obliterans organizing pneumonia
  • Diffuse alveolar damage
  • Eosinophilic pneumonia
  • Nonspecific interstitial pneumonia
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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