Drug-induced hypoglycemia: A systematic review

Mohammad H Murad, Fernando Coto-Yglesias, Amy T. Wang, Nasim Sheidaee, Rebecca J. Mullan, Mohamed B. Elamin, Patricia J. Erwin, Victor Manuel Montori

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Context: Drug-induced hypoglycemia is a significant adverse effect that may cause important morbidity. Objective: The aim of the study was to systematically review the literature for drugs reported to cause hypoglycemia and assess the quality of evidence and strength of association supporting this causal link. Data Sources: We searched electronic databases (MEDLINE, EMBASE, Web of Science, and SCOPUS) and the drug information system Micromedex through November 2007 and sought additional references from experts. Study Selection: Studies were eligible if they reported hypoglycemia as a side effect of a drug not used to treat hyperglycemia, regardless of their design, language, size, or follow-up duration. We excluded hypoglycemia caused by industrial exposures, nonpharmacological chemical exposures, alcohol, herbs, nutritional supplements, and in vitro and animal studies. Data Extraction: Reviewers extracted study characteristics and methodological quality and, when possible, data to estimate the odds of developing hypoglycemia when exposed to the offending agent. Data Synthesis: We found 448 eligible studies that described 2696 cases of hypoglycemia associated with 164 different drugs. The quality of evidence supporting associations between drugs and hypoglycemia was mostly very low due to methodological limitations and imprecision. The most commonly reported offending drugs were quinolones, pentamidine, quinine, beta blockers, an-giotensin-converting enzyme agents, and IGF. Conclusions: Very low quality evidence substantiates the association between hypoglycemia and the use of numerous nondiabetic drugs.

Original languageEnglish (US)
Pages (from-to)741-745
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number3
DOIs
StatePublished - Mar 2009

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Hypoglycemia
Pharmaceutical Preparations
Association reactions
Pentamidine
Quinine
Information Storage and Retrieval
Quinolones
Drug-Related Side Effects and Adverse Reactions
Information Systems
MEDLINE
Hyperglycemia
Animals
Information systems
Language
Alcohols
Databases
Morbidity
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Drug-induced hypoglycemia : A systematic review. / Murad, Mohammad H; Coto-Yglesias, Fernando; Wang, Amy T.; Sheidaee, Nasim; Mullan, Rebecca J.; Elamin, Mohamed B.; Erwin, Patricia J.; Montori, Victor Manuel.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 3, 03.2009, p. 741-745.

Research output: Contribution to journalArticle

Murad, MH, Coto-Yglesias, F, Wang, AT, Sheidaee, N, Mullan, RJ, Elamin, MB, Erwin, PJ & Montori, VM 2009, 'Drug-induced hypoglycemia: A systematic review', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 3, pp. 741-745. https://doi.org/10.1210/jc.2008-1416
Murad MH, Coto-Yglesias F, Wang AT, Sheidaee N, Mullan RJ, Elamin MB et al. Drug-induced hypoglycemia: A systematic review. Journal of Clinical Endocrinology and Metabolism. 2009 Mar;94(3):741-745. https://doi.org/10.1210/jc.2008-1416
Murad, Mohammad H ; Coto-Yglesias, Fernando ; Wang, Amy T. ; Sheidaee, Nasim ; Mullan, Rebecca J. ; Elamin, Mohamed B. ; Erwin, Patricia J. ; Montori, Victor Manuel. / Drug-induced hypoglycemia : A systematic review. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 3. pp. 741-745.
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