Abstract
Drosophila neurotactin is a transmembrane glycoprotein with an apparent molecular mass of 135 × 103. Neurotactin is regionally expressed at the cellular blastoderm stage; later in embryogenesis the expression of the protein becomes restricted to cells of the peripheral and central nervous system. Immunocytochemical localization shows neurotactin protein at points of cell-cell contact. Using the anti-neurotactin monoclonal antibody BP-106, a neurotactin cDNA was isolated that encodes a 846 residue polypeptide. The chromosomal location of the neurotactin gene is 73C. The extracellular domain at the carboxyterminal end of the neurotactin protein shows a strong structural and sequence homology to serine esterases without retaining the amino acids forming the active center. Neurotactin therefore belongs to a growing group of proteins including Drosophila glutactin and thyroglobulins that are known to share this serine esterase protein domain motif without retaining the active center of the enzyme.
Original language | English (US) |
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Pages (from-to) | 1327-1340 |
Number of pages | 14 |
Journal | Development |
Volume | 110 |
Issue number | 4 |
State | Published - Dec 1990 |
Keywords
- Drosophila neurodevelopment
- Glycoprotein
- Neurotactin
- Serine esterase domain
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology