Drosophila neurotactin, a surface glycoprotein with homology to serine esterases, is dynamically expressed during embryogenesis

M. Hortsch, N. H. Patel, A. J. Bieber, Z. R. Traquina, C. S. Goodman

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Drosophila neurotactin is a transmembrane glycoprotein with an apparent molecular mass of 135 x 103. Neurotactin is regionally expressed at the cellular blastoderm stage; later in embryogenesis the expression of the protein becomes restricted to cells of the peripheral and central nervous system. Immunocytochemical localization shows neurotactin protein at points of cell-cell contact. Using the anti-neurotactin monoclonal antibody BP-106, a neurotactin cDNA was isolated that encodes a 846 residue polypeptide. The chromosomal location of the neurotactin gene is 73C. The extracellular domain at the carboxyterminal end of the neurotactin protein shows a strong structural and sequence homology to serine esterases without retaining the amino acids forming the active center. Neurotactin therefore belongs to a growing group of proteins including Drosophila glutactin and thyroglobulins that are known to share this serine esterase protein domain motif without retaining the active center of the enzyme.

Original languageEnglish (US)
Pages (from-to)1327-1340
Number of pages14
JournalDevelopment
Volume110
Issue number4
StatePublished - Dec 1 1990

Keywords

  • Drosophila neurodevelopment
  • Glycoprotein
  • Neurotactin
  • Serine esterase domain

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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    Hortsch, M., Patel, N. H., Bieber, A. J., Traquina, Z. R., & Goodman, C. S. (1990). Drosophila neurotactin, a surface glycoprotein with homology to serine esterases, is dynamically expressed during embryogenesis. Development, 110(4), 1327-1340.