Drosophila neuroglian: A member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1

Allan J. Bieber, Peter M. Snow, Michael Hortsch, Nipam H. Patel, J. Roger Jacobs, Zaida R. Traquina, Jim Schilling, Corey S. Goodman

Research output: Contribution to journalArticlepeer-review

303 Scopus citations

Abstract

Drosophila neuroglian is an integral membrane glycoprotein that is expressed on a variety of cell types in the Drosophila embryo, including expression on a large subset of glial and neuronal cell bodies in the central and peripheral nervous systems and on the fasciculating axons that extend along them. Neurogllan cDNA clones were isolated by expression cloning. cDNA sequence analysis reveals that neuroglian is a member of the immunoglobulin superfamily. The extracellular portion of the protein consists of six immunoglobulin C2-type domains followed by five fibronectin type III domains. Neuroglian is closely related to the immunoglobulin-like vertebrate neural adhesion molecules and, among them, shows most extensive homology to mouse L1. Its homology to L1 and its embryonic localization suggest that neuroglian may play a role in neural and gllal cell adhesion in the developing Drosophila embryo. We report here on the identification of a lethal mutation in the neuroglian gene.

Original languageEnglish (US)
Pages (from-to)447-460
Number of pages14
JournalCell
Volume59
Issue number3
DOIs
StatePublished - Nov 3 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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