Drosophila fasciclin I is a novel homophilic adhesion molecule that along with fasciclin III can mediate cell sorting

Thomas Elkins, Michael Hortsch, Allan J. Bieber, Peter M. Snow, Corey S. Goodman

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Fasciclin I is a membrane-associated glycoprotein that is regionally expressed on a subset of fasciculating axons during neuronal development in insects; it is expressed on apposing cell surfaces, suggesting a role in specific cell adhesion. In this paper we show that Drosophila fasciclin I is a novel homophilic cell adhesion molecule. When the nonadhesive Drosophila S2 cells are transfected with the fasciclin I cDNA, they form aggregates that are blocked by antisera against fasciclin I. When cells expressing fasciclin I are mixed with cells expressing fasciclin III, another Drosophila homophilic adhesion molecule, the mixture sorts into aggregates homogeneous for either fasciclin I- or fasciclin III-expressing cells. The ability of these two novel adhesion molecules to mediate cell sorting in vitro suggests that they might play a similar role during neuronal development.

Original languageEnglish (US)
Pages (from-to)1825-1832
Number of pages8
JournalJournal of Cell Biology
Volume110
Issue number5
StatePublished - May 1990
Externally publishedYes

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Drosophila
Membrane Glycoproteins
Cell Adhesion Molecules
Cell Adhesion
Axons
Insects
fasciclin I
Immune Sera
Complementary DNA

ASJC Scopus subject areas

  • Cell Biology

Cite this

Elkins, T., Hortsch, M., Bieber, A. J., Snow, P. M., & Goodman, C. S. (1990). Drosophila fasciclin I is a novel homophilic adhesion molecule that along with fasciclin III can mediate cell sorting. Journal of Cell Biology, 110(5), 1825-1832.

Drosophila fasciclin I is a novel homophilic adhesion molecule that along with fasciclin III can mediate cell sorting. / Elkins, Thomas; Hortsch, Michael; Bieber, Allan J.; Snow, Peter M.; Goodman, Corey S.

In: Journal of Cell Biology, Vol. 110, No. 5, 05.1990, p. 1825-1832.

Research output: Contribution to journalArticle

Elkins, T, Hortsch, M, Bieber, AJ, Snow, PM & Goodman, CS 1990, 'Drosophila fasciclin I is a novel homophilic adhesion molecule that along with fasciclin III can mediate cell sorting', Journal of Cell Biology, vol. 110, no. 5, pp. 1825-1832.
Elkins, Thomas ; Hortsch, Michael ; Bieber, Allan J. ; Snow, Peter M. ; Goodman, Corey S. / Drosophila fasciclin I is a novel homophilic adhesion molecule that along with fasciclin III can mediate cell sorting. In: Journal of Cell Biology. 1990 ; Vol. 110, No. 5. pp. 1825-1832.
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