Downsizing genomic medicine: Approaching the ethical complexity of whole-genome sequencing by starting small

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

As we look to a time when whole-genome sequencing is integrated into patient care, it is possible to anticipate a number of ethical challenges that will need to be addressed. The most intractable of these concern informed consent and the responsible management of very large amounts of genetic information. Given the range of possible findings, it remains unclear to what extent it will be possible to obtain meaningful patient consent to genomic testing. Equally unclear is how clinicians will disseminate the enormous volume of genetic information produced by whole-genome sequencing. Toward developing practical strategies for managing these ethical challenges, we propose a research agenda that approaches multiplexed forms of clinical genetic testing as natural laboratories in which to develop best practices for managing the ethical complexities of genomic medicine.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalGenetics in Medicine
Volume13
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • ethical
  • informed consent
  • legal and social issues
  • personalized medicine
  • return of results
  • whole genome sequencing

ASJC Scopus subject areas

  • Genetics(clinical)

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