Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer

Mozammel H. Gazi; Mei Lan He; John C. Cheville; Charles Y.F. Young

doi:10.4161/cbt.7.1.5131

Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer

Mozammel H. Gazi, Mei Lan He, John C. Cheville, Charles Y.F. Young

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

By means of protein expression profile, mass spectral and/or RT-PCR analyses we found for the first time IgG Fc binding protein (FcγBP), distinct from Fcγ receptors is expressed in both human and mouse prostates. There is a strong correlation between downregulation of FcγBP and the progression of prostate cancer in Transgenic Adenocarcinoma Mouse Prostate (TRAMP) mice. FcγBP gene expression is significantly reduced or lost in human prostate tumor tissues and prostate cell lines. The differentially expressed FcγBP could reflect its potential role in prostate malignancy as well as an indicator for progression of the cancer.

Original language	English (US)
Pages (from-to)	70-75
Number of pages	6
Journal	Cancer Biology and Therapy
Volume	7
Issue number	1
DOIs	https://doi.org/10.4161/cbt.7.1.5131
State	Published - Jan 2008

Keywords

Fc binding protein
Prostate cancer
TRAMP

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

Access to Document

10.4161/cbt.7.1.5131

Cite this

@article{48a0359bfda8464ea52bd359f93e13a1,

title = "Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer",

abstract = "By means of protein expression profile, mass spectral and/or RT-PCR analyses we found for the first time IgG Fc binding protein (FcγBP), distinct from Fcγ receptors is expressed in both human and mouse prostates. There is a strong correlation between downregulation of FcγBP and the progression of prostate cancer in Transgenic Adenocarcinoma Mouse Prostate (TRAMP) mice. FcγBP gene expression is significantly reduced or lost in human prostate tumor tissues and prostate cell lines. The differentially expressed FcγBP could reflect its potential role in prostate malignancy as well as an indicator for progression of the cancer.",

keywords = "Fc binding protein, Prostate cancer, TRAMP",

author = "Gazi, {Mozammel H.} and He, {Mei Lan} and Cheville, {John C.} and Young, {Charles Y.F.}",

note = "Funding Information: The work in this manuscript is in part supported by NIH grants CA88900 and 91956. And there is no conflict about this manuscript.",

year = "2008",

month = jan,

doi = "10.4161/cbt.7.1.5131",

language = "English (US)",

volume = "7",

pages = "70--75",

journal = "Cancer Biology and Therapy",

issn = "1538-4047",

publisher = "Landes Bioscience",

number = "1",

}

TY - JOUR

T1 - Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer

AU - Gazi, Mozammel H.

AU - He, Mei Lan

AU - Cheville, John C.

AU - Young, Charles Y.F.

N1 - Funding Information: The work in this manuscript is in part supported by NIH grants CA88900 and 91956. And there is no conflict about this manuscript.

PY - 2008/1

Y1 - 2008/1

N2 - By means of protein expression profile, mass spectral and/or RT-PCR analyses we found for the first time IgG Fc binding protein (FcγBP), distinct from Fcγ receptors is expressed in both human and mouse prostates. There is a strong correlation between downregulation of FcγBP and the progression of prostate cancer in Transgenic Adenocarcinoma Mouse Prostate (TRAMP) mice. FcγBP gene expression is significantly reduced or lost in human prostate tumor tissues and prostate cell lines. The differentially expressed FcγBP could reflect its potential role in prostate malignancy as well as an indicator for progression of the cancer.

AB - By means of protein expression profile, mass spectral and/or RT-PCR analyses we found for the first time IgG Fc binding protein (FcγBP), distinct from Fcγ receptors is expressed in both human and mouse prostates. There is a strong correlation between downregulation of FcγBP and the progression of prostate cancer in Transgenic Adenocarcinoma Mouse Prostate (TRAMP) mice. FcγBP gene expression is significantly reduced or lost in human prostate tumor tissues and prostate cell lines. The differentially expressed FcγBP could reflect its potential role in prostate malignancy as well as an indicator for progression of the cancer.

KW - Fc binding protein

KW - Prostate cancer

KW - TRAMP

UR - http://www.scopus.com/inward/record.url?scp=42549126932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42549126932&partnerID=8YFLogxK

U2 - 10.4161/cbt.7.1.5131

DO - 10.4161/cbt.7.1.5131

M3 - Article

C2 - 17938577

AN - SCOPUS:42549126932

SN - 1538-4047

VL - 7

SP - 70

EP - 75

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 1

ER -

Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this