Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer

Mozammel H. Gazi, MeiLan He, John C. Cheville, Charles Y F Young

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

By means of protein expression profile, mass spectral and/or RT-PCR analyses we found for the first time IgG Fc binding protein (FcγBP), distinct from Fcγ receptors is expressed in both human and mouse prostates. There is a strong correlation between downregulation of FcγBP and the progression of prostate cancer in Transgenic Adenocarcinoma Mouse Prostate (TRAMP) mice. FcγBP gene expression is significantly reduced or lost in human prostate tumor tissues and prostate cell lines. The differentially expressed FcγBP could reflect its potential role in prostate malignancy as well as an indicator for progression of the cancer.

Original languageEnglish (US)
Pages (from-to)70-75
Number of pages6
JournalCancer Biology and Therapy
Volume7
Issue number1
StatePublished - Jan 2008

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Prostate
Prostatic Neoplasms
Carrier Proteins
Down-Regulation
Immunoglobulin G
Neoplasms
Fc Receptors
Transgenic Mice
Adenocarcinoma
Gene Expression
Cell Line
Polymerase Chain Reaction
Proteins

Keywords

  • Fc binding protein
  • Prostate cancer
  • TRAMP

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gazi, M. H., He, M., Cheville, J. C., & Young, C. Y. F. (2008). Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer. Cancer Biology and Therapy, 7(1), 70-75.

Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer. / Gazi, Mozammel H.; He, MeiLan; Cheville, John C.; Young, Charles Y F.

In: Cancer Biology and Therapy, Vol. 7, No. 1, 01.2008, p. 70-75.

Research output: Contribution to journalArticle

Gazi, MH, He, M, Cheville, JC & Young, CYF 2008, 'Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer', Cancer Biology and Therapy, vol. 7, no. 1, pp. 70-75.
Gazi MH, He M, Cheville JC, Young CYF. Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer. Cancer Biology and Therapy. 2008 Jan;7(1):70-75.
Gazi, Mozammel H. ; He, MeiLan ; Cheville, John C. ; Young, Charles Y F. / Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer. In: Cancer Biology and Therapy. 2008 ; Vol. 7, No. 1. pp. 70-75.
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