Doubling Down on BRCA-Mutated Cancer

Andrea E. Wahner Hendrickson; Scott H. Kaufmann; Elizabeth M. Swisher

doi:10.1016/j.trecan.2017.09.005

Doubling Down on BRCA-Mutated Cancer

Andrea E. Wahner Hendrickson, Scott H. Kaufmann, Elizabeth M. Swisher

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Immunotherapy is changing the landscape of cancer treatment. Nonetheless, not all malignancies respond, possibly due to low mutational load. Recent work in a TP53^−/− BRCA1-mutant murine breast cancer model indicates that double blockade with two immune checkpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival after DNA damaging chemotherapy, whereas single blockade does not. These findings suggest an approach to enhance the impact of immune checkpoint blockade in BRCA-mutated tumors.

Original language	English (US)
Pages (from-to)	743-744
Number of pages	2
Journal	Trends in Cancer
Volume	3
Issue number	11
DOIs	https://doi.org/10.1016/j.trecan.2017.09.005
State	Published - Nov 2017

Keywords

BRCA1
breast cancer
immune checkpoint
immunotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2017.09.005

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title = "Doubling Down on BRCA-Mutated Cancer",

abstract = "Immunotherapy is changing the landscape of cancer treatment. Nonetheless, not all malignancies respond, possibly due to low mutational load. Recent work in a TP53−/− BRCA1-mutant murine breast cancer model indicates that double blockade with two immune checkpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival after DNA damaging chemotherapy, whereas single blockade does not. These findings suggest an approach to enhance the impact of immune checkpoint blockade in BRCA-mutated tumors.",

keywords = "BRCA1, breast cancer, immune checkpoint, immunotherapy",

author = "{Wahner Hendrickson}, {Andrea E.} and Kaufmann, {Scott H.} and Swisher, {Elizabeth M.}",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = nov,

doi = "10.1016/j.trecan.2017.09.005",

language = "English (US)",

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AU - Wahner Hendrickson, Andrea E.

AU - Kaufmann, Scott H.

AU - Swisher, Elizabeth M.

PY - 2017/11

Y1 - 2017/11

N2 - Immunotherapy is changing the landscape of cancer treatment. Nonetheless, not all malignancies respond, possibly due to low mutational load. Recent work in a TP53−/− BRCA1-mutant murine breast cancer model indicates that double blockade with two immune checkpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival after DNA damaging chemotherapy, whereas single blockade does not. These findings suggest an approach to enhance the impact of immune checkpoint blockade in BRCA-mutated tumors.

AB - Immunotherapy is changing the landscape of cancer treatment. Nonetheless, not all malignancies respond, possibly due to low mutational load. Recent work in a TP53−/− BRCA1-mutant murine breast cancer model indicates that double blockade with two immune checkpoint inhibitors increases the number of tumor-infiltrating lymphocytes and overall survival after DNA damaging chemotherapy, whereas single blockade does not. These findings suggest an approach to enhance the impact of immune checkpoint blockade in BRCA-mutated tumors.

KW - BRCA1

KW - breast cancer

KW - immune checkpoint

KW - immunotherapy

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JO - Trends in Cancer

JF - Trends in Cancer

IS - 11

ER -

Doubling Down on BRCA-Mutated Cancer

Abstract

Keywords

ASJC Scopus subject areas

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