Double-blind study of botulinum A toxin injections into the gastrocnemius muscle in patients with cerebral palsy

David H. Sutherland, Kenton R. Kaufman, Marilynn P. Wyatt, Henry G. Chambers, Scott J. Mubarak

Research output: Contribution to journalArticlepeer-review

183 Scopus citations

Abstract

The purpose of this study was to quantify the gait of subjects receiving two injections of either botulinum A toxin or saline vehicle into the gastrocnemius muscle(s). The study group consisted of cerebral palsy patients who walked with an equinus gait pattern. This study was a randomized, double-blinded, parallel clinical trial of 20 subjects. All were studied by gait analysis before and after the injections. There were no adverse effects. Peak ankle dorsiflexion in stance and swing significantly improved in subjects who received the drug and not in controls. Results of this double blind study give support to the short term efficacy of botulinum toxin A to improve gait in selected patients with cerebral palsy. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalGait and Posture
Volume10
Issue number1
DOIs
StatePublished - Sep 1 1999

Keywords

  • Botulinum A toxin
  • Cerebral palsy
  • Double-blind study
  • Equinus
  • Gait

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Rehabilitation

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