Dose-volume analysis of radiation-induced optic neuropathy after single-fraction stereotactic radiosurgery

Bruce E. Pollock, Michael J. Link, Jacqueline A. Leavitt, Scott L. Stafford

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

BACKGROUND: The risk of radiation-induced optic neuropathy (RION) is the primary limitation of single-fraction stereotactic radiosurgery (SRS) for many patients with parasellar lesions.

OBJECTIVE: To define the normal tissue complication probability of the anterior visual pathways (AVPs) after single-fraction SRS.

METHODS: Retrospective review comparing visual function before and after SRS in 133 patients (266 sides) with pituitary adenomas having SRS between October 2007 and July 2012. Patients with prior radiation therapy or SRS were excluded. The median follow-up after SRS was 32 months.

RESULTS: The median maximum point dose to the AVP was 9.2 Gy (interquartile range [IQR], 6.9-10.8). One hundred seventy-four sides (65%) received .8 Gy: The median 8-Gy volume was 15.8 mm3 (IQR, 3.7-36.2). Ninety-four sides (35%) received .10 Gy; the median 10-Gy volume was 1.6 mm3 (IQR, 0.5-5.3). Twenty-nine sides (11%) received .12 Gy; the median 12-Gy volume was 0.1 mm3 (IQR, 0.1-0.6). No patient had a RION after SRS. The chances of developing a RION at the 8-Gy, 10-Gy, and 12-Gy volumes (95% confidence interval) in this series were 0% to 2.6%, 0% to 4.7%, and 0% to 13.9%, respectively.

CONCLUSION: The AVP in patients without prior radiation treatments can safely receive radiation doses up to 12 Gy with a low risk of RION. Although additional studies are needed to better delineate the normal tissue complication probability of the AVP, adherence to the AVP radiation tolerance guidelines developed 20 years ago (8 Gy) limits the applicability and potentially the effectiveness of single-fraction SRS for patients with lesions in the parasellar region.

Original languageEnglish (US)
Pages (from-to)456-460
Number of pages5
JournalNeurosurgery
Volume75
Issue number4
DOIs
StatePublished - 2014

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Optic Nerve Diseases
Radiosurgery
Visual Pathways
Radiation
Radiation Tolerance
Pituitary Neoplasms
Radiotherapy
Guidelines
Confidence Intervals

Keywords

  • Complication
  • Optic nerve
  • Radiation
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Medicine(all)

Cite this

Dose-volume analysis of radiation-induced optic neuropathy after single-fraction stereotactic radiosurgery. / Pollock, Bruce E.; Link, Michael J.; Leavitt, Jacqueline A.; Stafford, Scott L.

In: Neurosurgery, Vol. 75, No. 4, 2014, p. 456-460.

Research output: Contribution to journalArticle

Pollock, Bruce E. ; Link, Michael J. ; Leavitt, Jacqueline A. ; Stafford, Scott L. / Dose-volume analysis of radiation-induced optic neuropathy after single-fraction stereotactic radiosurgery. In: Neurosurgery. 2014 ; Vol. 75, No. 4. pp. 456-460.
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abstract = "BACKGROUND: The risk of radiation-induced optic neuropathy (RION) is the primary limitation of single-fraction stereotactic radiosurgery (SRS) for many patients with parasellar lesions.OBJECTIVE: To define the normal tissue complication probability of the anterior visual pathways (AVPs) after single-fraction SRS.METHODS: Retrospective review comparing visual function before and after SRS in 133 patients (266 sides) with pituitary adenomas having SRS between October 2007 and July 2012. Patients with prior radiation therapy or SRS were excluded. The median follow-up after SRS was 32 months.RESULTS: The median maximum point dose to the AVP was 9.2 Gy (interquartile range [IQR], 6.9-10.8). One hundred seventy-four sides (65{\%}) received .8 Gy: The median 8-Gy volume was 15.8 mm3 (IQR, 3.7-36.2). Ninety-four sides (35{\%}) received .10 Gy; the median 10-Gy volume was 1.6 mm3 (IQR, 0.5-5.3). Twenty-nine sides (11{\%}) received .12 Gy; the median 12-Gy volume was 0.1 mm3 (IQR, 0.1-0.6). No patient had a RION after SRS. The chances of developing a RION at the 8-Gy, 10-Gy, and 12-Gy volumes (95{\%} confidence interval) in this series were 0{\%} to 2.6{\%}, 0{\%} to 4.7{\%}, and 0{\%} to 13.9{\%}, respectively.CONCLUSION: The AVP in patients without prior radiation treatments can safely receive radiation doses up to 12 Gy with a low risk of RION. Although additional studies are needed to better delineate the normal tissue complication probability of the AVP, adherence to the AVP radiation tolerance guidelines developed 20 years ago (8 Gy) limits the applicability and potentially the effectiveness of single-fraction SRS for patients with lesions in the parasellar region.",
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AU - Pollock, Bruce E.

AU - Link, Michael J.

AU - Leavitt, Jacqueline A.

AU - Stafford, Scott L.

PY - 2014

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N2 - BACKGROUND: The risk of radiation-induced optic neuropathy (RION) is the primary limitation of single-fraction stereotactic radiosurgery (SRS) for many patients with parasellar lesions.OBJECTIVE: To define the normal tissue complication probability of the anterior visual pathways (AVPs) after single-fraction SRS.METHODS: Retrospective review comparing visual function before and after SRS in 133 patients (266 sides) with pituitary adenomas having SRS between October 2007 and July 2012. Patients with prior radiation therapy or SRS were excluded. The median follow-up after SRS was 32 months.RESULTS: The median maximum point dose to the AVP was 9.2 Gy (interquartile range [IQR], 6.9-10.8). One hundred seventy-four sides (65%) received .8 Gy: The median 8-Gy volume was 15.8 mm3 (IQR, 3.7-36.2). Ninety-four sides (35%) received .10 Gy; the median 10-Gy volume was 1.6 mm3 (IQR, 0.5-5.3). Twenty-nine sides (11%) received .12 Gy; the median 12-Gy volume was 0.1 mm3 (IQR, 0.1-0.6). No patient had a RION after SRS. The chances of developing a RION at the 8-Gy, 10-Gy, and 12-Gy volumes (95% confidence interval) in this series were 0% to 2.6%, 0% to 4.7%, and 0% to 13.9%, respectively.CONCLUSION: The AVP in patients without prior radiation treatments can safely receive radiation doses up to 12 Gy with a low risk of RION. Although additional studies are needed to better delineate the normal tissue complication probability of the AVP, adherence to the AVP radiation tolerance guidelines developed 20 years ago (8 Gy) limits the applicability and potentially the effectiveness of single-fraction SRS for patients with lesions in the parasellar region.

AB - BACKGROUND: The risk of radiation-induced optic neuropathy (RION) is the primary limitation of single-fraction stereotactic radiosurgery (SRS) for many patients with parasellar lesions.OBJECTIVE: To define the normal tissue complication probability of the anterior visual pathways (AVPs) after single-fraction SRS.METHODS: Retrospective review comparing visual function before and after SRS in 133 patients (266 sides) with pituitary adenomas having SRS between October 2007 and July 2012. Patients with prior radiation therapy or SRS were excluded. The median follow-up after SRS was 32 months.RESULTS: The median maximum point dose to the AVP was 9.2 Gy (interquartile range [IQR], 6.9-10.8). One hundred seventy-four sides (65%) received .8 Gy: The median 8-Gy volume was 15.8 mm3 (IQR, 3.7-36.2). Ninety-four sides (35%) received .10 Gy; the median 10-Gy volume was 1.6 mm3 (IQR, 0.5-5.3). Twenty-nine sides (11%) received .12 Gy; the median 12-Gy volume was 0.1 mm3 (IQR, 0.1-0.6). No patient had a RION after SRS. The chances of developing a RION at the 8-Gy, 10-Gy, and 12-Gy volumes (95% confidence interval) in this series were 0% to 2.6%, 0% to 4.7%, and 0% to 13.9%, respectively.CONCLUSION: The AVP in patients without prior radiation treatments can safely receive radiation doses up to 12 Gy with a low risk of RION. Although additional studies are needed to better delineate the normal tissue complication probability of the AVP, adherence to the AVP radiation tolerance guidelines developed 20 years ago (8 Gy) limits the applicability and potentially the effectiveness of single-fraction SRS for patients with lesions in the parasellar region.

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KW - Optic nerve

KW - Radiation

KW - Stereotactic radiosurgery

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