Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia

Sebastiaan Engelborghs; Bart Dermaut; Peter Mariën; Anoek Symons; Ellen Vloeberghs; Karen Maertens; Nore Somers; Johan Goeman; Rosa Rademakers; Marleen Van Den Broeck; Barbara Pickut; Marc Cruts; Christine Van Broeckhoven; Peter P. De Deyn

doi:10.1016/j.neurobiolaging.2005.02.005

Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia

Sebastiaan Engelborghs, Bart Dermaut, Peter Mariën, Anoek Symons, Ellen Vloeberghs, Karen Maertens, Nore Somers, Johan Goeman, Rosa Rademakers, Marleen Van Den Broeck, Barbara Pickut, Marc Cruts, Christine Van Broeckhoven, Peter P. De Deyn

Neuroscience

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N = 186), frontotemporal dementia (FTD) (N = 29), mixed dementia (MXD) (N = 28), dementia with Lewy bodies (DLB) (N = 11) and Parkinson's disease dementia (PDD) (N = 7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)). In FTD patients, we identified dose dependent effects of APOE ε4 on the Behave-AD total and cluster aggressiveness scores. APOE ε2 was associated with a higher score on the Behave-AD cluster delusions in PDD/DLB patients. No APOE effects on frequency or severity of BPSD in AD and MXD patients were found. In conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE ε4 with aggression (FTD) and of APOE ε2 with delusions (PDD/DLB).

Original language	English (US)
Pages (from-to)	285-292
Number of pages	8
Journal	Neurobiology of aging
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.neurobiolaging.2005.02.005
State	Published - Feb 2006

Keywords

APOE
Aggressiveness
Alzheimer's disease
Anxiety
BPSD
Behavior
Delusions
Dementia
Frontotemporal dementia
Hallucinations
Psychosis

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2005.02.005

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Engelborghs, S., Dermaut, B., Mariën, P., Symons, A., Vloeberghs, E., Maertens, K., Somers, N., Goeman, J., Rademakers, R., Van Den Broeck, M., Pickut, B., Cruts, M., Van Broeckhoven, C., & De Deyn, P. P. (2006). Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia. Neurobiology of aging, 27(2), 285-292. https://doi.org/10.1016/j.neurobiolaging.2005.02.005

Engelborghs, S, Dermaut, B, Mariën, P, Symons, A, Vloeberghs, E, Maertens, K, Somers, N, Goeman, J, Rademakers, R, Van Den Broeck, M, Pickut, B, Cruts, M, Van Broeckhoven, C & De Deyn, PP 2006, 'Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia', Neurobiology of aging, vol. 27, no. 2, pp. 285-292. https://doi.org/10.1016/j.neurobiolaging.2005.02.005

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title = "Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia",

abstract = "To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N = 186), frontotemporal dementia (FTD) (N = 29), mixed dementia (MXD) (N = 28), dementia with Lewy bodies (DLB) (N = 11) and Parkinson's disease dementia (PDD) (N = 7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)). In FTD patients, we identified dose dependent effects of APOE ε4 on the Behave-AD total and cluster aggressiveness scores. APOE ε2 was associated with a higher score on the Behave-AD cluster delusions in PDD/DLB patients. No APOE effects on frequency or severity of BPSD in AD and MXD patients were found. In conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE ε4 with aggression (FTD) and of APOE ε2 with delusions (PDD/DLB).",

keywords = "APOE, Aggressiveness, Alzheimer's disease, Anxiety, BPSD, Behavior, Delusions, Dementia, Frontotemporal dementia, Hallucinations, Psychosis",

author = "Sebastiaan Engelborghs and Bart Dermaut and Peter Mari{\"e}n and Anoek Symons and Ellen Vloeberghs and Karen Maertens and Nore Somers and Johan Goeman and Rosa Rademakers and {Van Den Broeck}, Marleen and Barbara Pickut and Marc Cruts and {Van Broeckhoven}, Christine and {De Deyn}, {Peter P.}",

note = "Funding Information: The authors acknowledge the technical skills of Samira Bel Kacem and Frans Aerts in the processing of the blood samples. This research was supported by the Born-Bunge Foundation, the University of Antwerp, Neurosearch Antwerp, the Fund for Scientific Research-Flanders (FWO-F), the International Alzheimer Research Foundation, the Interuniversity Attraction Poles program P5/19 of the Federal Science Policy Office, Belgium and by a Ph.D. grant of the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen). R.R., B.D. and S.E. are Ph.D. fellows, and M.C. a postdoctoral fellow, of the Fund for Scientific Research-Flanders (FWO-F). ",

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AU - Engelborghs, Sebastiaan

AU - Dermaut, Bart

AU - Mariën, Peter

AU - Symons, Anoek

AU - Vloeberghs, Ellen

AU - Maertens, Karen

AU - Somers, Nore

AU - Goeman, Johan

AU - Rademakers, Rosa

AU - Van Den Broeck, Marleen

AU - Pickut, Barbara

AU - Cruts, Marc

AU - Van Broeckhoven, Christine

AU - De Deyn, Peter P.

N1 - Funding Information: The authors acknowledge the technical skills of Samira Bel Kacem and Frans Aerts in the processing of the blood samples. This research was supported by the Born-Bunge Foundation, the University of Antwerp, Neurosearch Antwerp, the Fund for Scientific Research-Flanders (FWO-F), the International Alzheimer Research Foundation, the Interuniversity Attraction Poles program P5/19 of the Federal Science Policy Office, Belgium and by a Ph.D. grant of the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen). R.R., B.D. and S.E. are Ph.D. fellows, and M.C. a postdoctoral fellow, of the Fund for Scientific Research-Flanders (FWO-F).

PY - 2006/2

Y1 - 2006/2

N2 - To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N = 186), frontotemporal dementia (FTD) (N = 29), mixed dementia (MXD) (N = 28), dementia with Lewy bodies (DLB) (N = 11) and Parkinson's disease dementia (PDD) (N = 7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)). In FTD patients, we identified dose dependent effects of APOE ε4 on the Behave-AD total and cluster aggressiveness scores. APOE ε2 was associated with a higher score on the Behave-AD cluster delusions in PDD/DLB patients. No APOE effects on frequency or severity of BPSD in AD and MXD patients were found. In conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE ε4 with aggression (FTD) and of APOE ε2 with delusions (PDD/DLB).

AB - To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N = 186), frontotemporal dementia (FTD) (N = 29), mixed dementia (MXD) (N = 28), dementia with Lewy bodies (DLB) (N = 11) and Parkinson's disease dementia (PDD) (N = 7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)). In FTD patients, we identified dose dependent effects of APOE ε4 on the Behave-AD total and cluster aggressiveness scores. APOE ε2 was associated with a higher score on the Behave-AD cluster delusions in PDD/DLB patients. No APOE effects on frequency or severity of BPSD in AD and MXD patients were found. In conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE ε4 with aggression (FTD) and of APOE ε2 with delusions (PDD/DLB).

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KW - Behavior

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KW - Frontotemporal dementia

KW - Hallucinations

KW - Psychosis

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Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia

Abstract

Keywords

ASJC Scopus subject areas

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