Dosage determination of ultrasmall particles of iron oxide for the delineation of microvasculature in the wistar rat brain

Ming Yang, Gregory A. Christoforidis, Tatiana Figueredo, Johannes T. Heverhagen, Amir Abduljalil, Michael V. Knopp

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Purpose: This investigation sought to optimize ultrasmall particles of iron oxide (USPIO) contrast agent dosage for visualizing cerebral microvasculature on an 8.0-Tesla ultra high field magnetic resonance imaging system. Materials and Methods: USPIO contrast agent was intravenously administered to 3 groups of 4 rats at 1,2, and 3 mg Fe/kg. Each animal was scanned before and after injection of USPIO using a high resolution T2*-weighted gradient recalled echo sequence with an in-plane resolution of 78 μm. The signal-to-noise ratio (SNR) and the number of microvessels visualized within the cortex and basal ganglia were calculated and compared before and after the administration of USPIO. Results: As the USPIO dose increased, microvascular conspicuity increased, and SNR decreased. A dosage of 2 mg Fe/kg improved microvascular visualization in both cortex and basal ganglion regions relative to 1 mg Fe/kg without significantly sacrificing SNR as was the case at 3 mg Fe/kg. Conclusion: Two mg Fe/kg USPIO is an optimal dose when imaging normal rat cerebral microvasculature using GRE T2*-weighted MR imaging at a field strength of 8 T.

Original languageEnglish (US)
Pages (from-to)655-660
Number of pages6
JournalInvestigative radiology
Volume40
Issue number10
DOIs
StatePublished - Oct 2005

Keywords

  • Brain
  • Magnetic resonance imaging
  • Microvasculature
  • USPIO

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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