Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion

Josef Korinek, Partho P. Sengupta, Jianwen Wang, Abel Romero-Corral, Anna E. Boukatina, Jan Vitek, Vijay K. Krishnamoorthy, Stephen S. Cha, Petras P Dzeja, Andre Terzic, Bijoy K. Khandheria, Marek Belohlavek

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Capitalizing on mechanoenergetic coupling, we investigated whether strain echocardiography can noninvasively estimate the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP), a marker of energetic status during acute myocardial ischemia and reperfusion. Methods: Twenty-eight pigs were divided into 7 groups (1 baseline, 4 ischemic, and 2 reperfusion). Ischemia was induced by left anterior descending coronary artery occlusion. Longitudinal systolic lengthening (SL) and postsystolic shortening (PSS) strain were measured by echocardiography. The ATP/ADP ratio was obtained from myocardial biopsies in the ischemic and control regions. Results: SL and PSS strain and the ATP/ADP ratio progressively decreased (P < .05) with increased duration (12, 40, 120, and 200 minutes) of ischemia. A mathematical formula (ATP/ADP = -0.97 + 0.25 × PSS strain + 0.20 × SL strain) estimated best the ATP/ADP ratio (r = 0.94, P < .05). Reperfusion after 12 but not after 120 minutes of ischemia significantly improved the ATP/ADP ratio and decreased SL and PSS strain. Conclusions: Strain echocardiography closely reflected changes and enabled the noninvasive estimation of the ATP/ADP ratio. A higher ATP/ADP ratio is associated with functional improvement after reperfusion.

Original languageEnglish (US)
Pages (from-to)961-968
Number of pages8
JournalJournal of the American Society of Echocardiography
Volume21
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

Adenosine Diphosphate
Reperfusion
Ischemia
Adenosine Triphosphate
Echocardiography
Myocardial Reperfusion
Coronary Occlusion
Myocardial Ischemia
Coronary Vessels
Swine
Biopsy

Keywords

  • Energy phosphates
  • Ischemia
  • Strain echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion. / Korinek, Josef; Sengupta, Partho P.; Wang, Jianwen; Romero-Corral, Abel; Boukatina, Anna E.; Vitek, Jan; Krishnamoorthy, Vijay K.; Cha, Stephen S.; Dzeja, Petras P; Terzic, Andre; Khandheria, Bijoy K.; Belohlavek, Marek.

In: Journal of the American Society of Echocardiography, Vol. 21, No. 8, 08.2008, p. 961-968.

Research output: Contribution to journalArticle

Korinek, Josef ; Sengupta, Partho P. ; Wang, Jianwen ; Romero-Corral, Abel ; Boukatina, Anna E. ; Vitek, Jan ; Krishnamoorthy, Vijay K. ; Cha, Stephen S. ; Dzeja, Petras P ; Terzic, Andre ; Khandheria, Bijoy K. ; Belohlavek, Marek. / Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion. In: Journal of the American Society of Echocardiography. 2008 ; Vol. 21, No. 8. pp. 961-968.
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AU - Korinek, Josef

AU - Sengupta, Partho P.

AU - Wang, Jianwen

AU - Romero-Corral, Abel

AU - Boukatina, Anna E.

AU - Vitek, Jan

AU - Krishnamoorthy, Vijay K.

AU - Cha, Stephen S.

AU - Dzeja, Petras P

AU - Terzic, Andre

AU - Khandheria, Bijoy K.

AU - Belohlavek, Marek

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N2 - Background: Capitalizing on mechanoenergetic coupling, we investigated whether strain echocardiography can noninvasively estimate the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP), a marker of energetic status during acute myocardial ischemia and reperfusion. Methods: Twenty-eight pigs were divided into 7 groups (1 baseline, 4 ischemic, and 2 reperfusion). Ischemia was induced by left anterior descending coronary artery occlusion. Longitudinal systolic lengthening (SL) and postsystolic shortening (PSS) strain were measured by echocardiography. The ATP/ADP ratio was obtained from myocardial biopsies in the ischemic and control regions. Results: SL and PSS strain and the ATP/ADP ratio progressively decreased (P < .05) with increased duration (12, 40, 120, and 200 minutes) of ischemia. A mathematical formula (ATP/ADP = -0.97 + 0.25 × PSS strain + 0.20 × SL strain) estimated best the ATP/ADP ratio (r = 0.94, P < .05). Reperfusion after 12 but not after 120 minutes of ischemia significantly improved the ATP/ADP ratio and decreased SL and PSS strain. Conclusions: Strain echocardiography closely reflected changes and enabled the noninvasive estimation of the ATP/ADP ratio. A higher ATP/ADP ratio is associated with functional improvement after reperfusion.

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