Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion

Josef Korinek; Partho P. Sengupta; Jianwen Wang; Abel Romero-Corral; Anna E. Boukatina; Jan Vitek; Vijay K. Krishnamoorthy; Stephen S. Cha; Petras P. Dzeja; Andre Terzic; Bijoy K. Khandheria; Marek Belohlavek

doi:10.1016/j.echo.2008.01.010

Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion

Josef Korinek, Partho P. Sengupta, Jianwen Wang, Abel Romero-Corral, Anna E. Boukatina, Jan Vitek, Vijay K. Krishnamoorthy, Stephen S. Cha, Petras P. Dzeja, Andre Terzic, Bijoy K. Khandheria, Marek Belohlavek

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Capitalizing on mechanoenergetic coupling, we investigated whether strain echocardiography can noninvasively estimate the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP), a marker of energetic status during acute myocardial ischemia and reperfusion. Methods: Twenty-eight pigs were divided into 7 groups (1 baseline, 4 ischemic, and 2 reperfusion). Ischemia was induced by left anterior descending coronary artery occlusion. Longitudinal systolic lengthening (SL) and postsystolic shortening (PSS) strain were measured by echocardiography. The ATP/ADP ratio was obtained from myocardial biopsies in the ischemic and control regions. Results: SL and PSS strain and the ATP/ADP ratio progressively decreased (P < .05) with increased duration (12, 40, 120, and 200 minutes) of ischemia. A mathematical formula (ATP/ADP = -0.97 + 0.25 × PSS strain + 0.20 × SL strain) estimated best the ATP/ADP ratio (r = 0.94, P < .05). Reperfusion after 12 but not after 120 minutes of ischemia significantly improved the ATP/ADP ratio and decreased SL and PSS strain. Conclusions: Strain echocardiography closely reflected changes and enabled the noninvasive estimation of the ATP/ADP ratio. A higher ATP/ADP ratio is associated with functional improvement after reperfusion.

Original language	English (US)
Pages (from-to)	961-968
Number of pages	8
Journal	Journal of the American Society of Echocardiography
Volume	21
Issue number	8
DOIs	https://doi.org/10.1016/j.echo.2008.01.010
State	Published - Aug 2008

Keywords

Energy phosphates
Ischemia
Strain echocardiography

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/j.echo.2008.01.010

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Korinek, J., Sengupta, P. P., Wang, J., Romero-Corral, A., Boukatina, A. E., Vitek, J., Krishnamoorthy, V. K., Cha, S. S., Dzeja, P. P., Terzic, A., Khandheria, B. K., & Belohlavek, M. (2008). Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion. Journal of the American Society of Echocardiography, 21(8), 961-968. https://doi.org/10.1016/j.echo.2008.01.010

Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion. / Korinek, Josef; Sengupta, Partho P.; Wang, Jianwen et al.
In: Journal of the American Society of Echocardiography, Vol. 21, No. 8, 08.2008, p. 961-968.

Research output: Contribution to journal › Article › peer-review

Korinek, J, Sengupta, PP, Wang, J, Romero-Corral, A, Boukatina, AE, Vitek, J, Krishnamoorthy, VK, Cha, SS, Dzeja, PP, Terzic, A, Khandheria, BK & Belohlavek, M 2008, 'Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion', Journal of the American Society of Echocardiography, vol. 21, no. 8, pp. 961-968. https://doi.org/10.1016/j.echo.2008.01.010

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title = "Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion",

abstract = "Background: Capitalizing on mechanoenergetic coupling, we investigated whether strain echocardiography can noninvasively estimate the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP), a marker of energetic status during acute myocardial ischemia and reperfusion. Methods: Twenty-eight pigs were divided into 7 groups (1 baseline, 4 ischemic, and 2 reperfusion). Ischemia was induced by left anterior descending coronary artery occlusion. Longitudinal systolic lengthening (SL) and postsystolic shortening (PSS) strain were measured by echocardiography. The ATP/ADP ratio was obtained from myocardial biopsies in the ischemic and control regions. Results: SL and PSS strain and the ATP/ADP ratio progressively decreased (P < .05) with increased duration (12, 40, 120, and 200 minutes) of ischemia. A mathematical formula (ATP/ADP = -0.97 + 0.25 × PSS strain + 0.20 × SL strain) estimated best the ATP/ADP ratio (r = 0.94, P < .05). Reperfusion after 12 but not after 120 minutes of ischemia significantly improved the ATP/ADP ratio and decreased SL and PSS strain. Conclusions: Strain echocardiography closely reflected changes and enabled the noninvasive estimation of the ATP/ADP ratio. A higher ATP/ADP ratio is associated with functional improvement after reperfusion.",

keywords = "Energy phosphates, Ischemia, Strain echocardiography",

author = "Josef Korinek and Sengupta, {Partho P.} and Jianwen Wang and Abel Romero-Corral and Boukatina, {Anna E.} and Jan Vitek and Krishnamoorthy, {Vijay K.} and Cha, {Stephen S.} and Dzeja, {Petras P.} and Andre Terzic and Khandheria, {Bijoy K.} and Marek Belohlavek",

note = "Funding Information: This study was supported by National Institutes of Health grant HL 68555 (M.B.) and in part by an American Society of Echocardiography grant (J.K.). Funding Information: Disclosure: Dr Belohlavek's research is funded in part by GE Healthcare. ",

year = "2008",

month = aug,

doi = "10.1016/j.echo.2008.01.010",

language = "English (US)",

volume = "21",

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T1 - Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion

AU - Korinek, Josef

AU - Sengupta, Partho P.

AU - Wang, Jianwen

AU - Romero-Corral, Abel

AU - Boukatina, Anna E.

AU - Vitek, Jan

AU - Krishnamoorthy, Vijay K.

AU - Cha, Stephen S.

AU - Dzeja, Petras P.

AU - Terzic, Andre

AU - Khandheria, Bijoy K.

AU - Belohlavek, Marek

N1 - Funding Information: This study was supported by National Institutes of Health grant HL 68555 (M.B.) and in part by an American Society of Echocardiography grant (J.K.). Funding Information: Disclosure: Dr Belohlavek's research is funded in part by GE Healthcare.

PY - 2008/8

Y1 - 2008/8

N2 - Background: Capitalizing on mechanoenergetic coupling, we investigated whether strain echocardiography can noninvasively estimate the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP), a marker of energetic status during acute myocardial ischemia and reperfusion. Methods: Twenty-eight pigs were divided into 7 groups (1 baseline, 4 ischemic, and 2 reperfusion). Ischemia was induced by left anterior descending coronary artery occlusion. Longitudinal systolic lengthening (SL) and postsystolic shortening (PSS) strain were measured by echocardiography. The ATP/ADP ratio was obtained from myocardial biopsies in the ischemic and control regions. Results: SL and PSS strain and the ATP/ADP ratio progressively decreased (P < .05) with increased duration (12, 40, 120, and 200 minutes) of ischemia. A mathematical formula (ATP/ADP = -0.97 + 0.25 × PSS strain + 0.20 × SL strain) estimated best the ATP/ADP ratio (r = 0.94, P < .05). Reperfusion after 12 but not after 120 minutes of ischemia significantly improved the ATP/ADP ratio and decreased SL and PSS strain. Conclusions: Strain echocardiography closely reflected changes and enabled the noninvasive estimation of the ATP/ADP ratio. A higher ATP/ADP ratio is associated with functional improvement after reperfusion.

AB - Background: Capitalizing on mechanoenergetic coupling, we investigated whether strain echocardiography can noninvasively estimate the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP), a marker of energetic status during acute myocardial ischemia and reperfusion. Methods: Twenty-eight pigs were divided into 7 groups (1 baseline, 4 ischemic, and 2 reperfusion). Ischemia was induced by left anterior descending coronary artery occlusion. Longitudinal systolic lengthening (SL) and postsystolic shortening (PSS) strain were measured by echocardiography. The ATP/ADP ratio was obtained from myocardial biopsies in the ischemic and control regions. Results: SL and PSS strain and the ATP/ADP ratio progressively decreased (P < .05) with increased duration (12, 40, 120, and 200 minutes) of ischemia. A mathematical formula (ATP/ADP = -0.97 + 0.25 × PSS strain + 0.20 × SL strain) estimated best the ATP/ADP ratio (r = 0.94, P < .05). Reperfusion after 12 but not after 120 minutes of ischemia significantly improved the ATP/ADP ratio and decreased SL and PSS strain. Conclusions: Strain echocardiography closely reflected changes and enabled the noninvasive estimation of the ATP/ADP ratio. A higher ATP/ADP ratio is associated with functional improvement after reperfusion.

KW - Energy phosphates

KW - Ischemia

KW - Strain echocardiography

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SN - 0894-7317

VL - 21

SP - 961

EP - 968

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

IS - 8

ER -

Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion

Abstract

Keywords

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