Abstract
Percutaneous transendocardial injections of therapeutic agents into the myocardium may not always be effective. We used an animal model for assessing the efficacy of the injections using linoleic acid as a testing agent. Efficacious delivery into the myocardium of a beating heart was indicated by rapidly developed local myocardial necrosis and wall motion abnormalities using echocardiography. We employed this experimental model to test our innovative technology, an acoustically active injection catheter. The Doppler ultrasound-guided acoustically active injection catheter effectively delivers the substance to the myocardium but needs further technical improvements to minimize an unwanted systemic distribution of the agent.
Original language | English (US) |
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Pages (from-to) | 749-762 |
Number of pages | 14 |
Journal | Journal of Ultrasound in Medicine |
Volume | 41 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2022 |
Keywords
- acoustic catheter
- color flow Doppler
- experimental model
- image guidance
- ultrasound
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging