Doppler echocardiography - Right heart catheterization relationships in patients with idiopathic pulmonary fibrosis and suspected pulmonary hypertension

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Pulmonary hypertension occurs commonly in patients with interstitial lung disease but is frequently not diagnosed or, if diagnosed, not further evaluated. In this study, we wanted to determine the accuracy of right ventricular systolic pressure measured by transthoracic Doppler echocardiography compared with hemodynamic measurements taken at right heart catheterization in patients with idiopathic pulmonary fibrosis who had suspected pulmonary hypertension. Material/Methods: Right heart catheterization was conducted if pulmonary hypertension was suggested by echocardiography - right ventricular systolic pressure >40 mm Hg. Pulmonary hypertension was defined by right heart catheterization as mean pulmonary artery pressure ≥25 mm Hg and pulmonary artery occlusion pressure ≤15 mm Hg. Results: Right heart catheterization demonstrated pulmonary hypertension in 75% while no pulmonary hypertension was confirmed in 12%. Correlations existed between right ventricular systolic pressure with pulmonary artery systolic pressure (r=0.66; p<0.0001) and mean pulmonary artery pressure (r=0.69; p<0.0001). Bland-Altman analysis illustrated the mean difference between the two methods was 7.75 mm Hg. Conclusions: Pulmonary hypertension occurs commonly in IPF. Accurate classification of pulmonary hemodynamics and degree of pulmonary hypertension severity require right heart catheterization. Prospective screening Doppler echocardiography and pulmonary hypertension therapeutic interventions warrant further prospective study in idiopathic pulmonary fibrosis.

Original languageEnglish (US)
JournalMedical Science Monitor
Volume14
Issue number4
StatePublished - Apr 2008

Fingerprint

Idiopathic Pulmonary Fibrosis
Doppler Echocardiography
Cardiac Catheterization
Pulmonary Hypertension
Pulmonary Artery
Ventricular Pressure
Blood Pressure
Pressure
Echocardiography
Hemodynamics
Interstitial Lung Diseases
Prospective Studies
Lung

Keywords

  • Doppler echocardiography
  • Interstitial lung disease: Clinical manifestations
  • Lung fibrosis
  • Pulmonary fibrosis and hypertension
  • Right heart catheterization

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{a4f349cdbc3a47dab52afb08163ea2ce,
title = "Doppler echocardiography - Right heart catheterization relationships in patients with idiopathic pulmonary fibrosis and suspected pulmonary hypertension",
abstract = "Background: Pulmonary hypertension occurs commonly in patients with interstitial lung disease but is frequently not diagnosed or, if diagnosed, not further evaluated. In this study, we wanted to determine the accuracy of right ventricular systolic pressure measured by transthoracic Doppler echocardiography compared with hemodynamic measurements taken at right heart catheterization in patients with idiopathic pulmonary fibrosis who had suspected pulmonary hypertension. Material/Methods: Right heart catheterization was conducted if pulmonary hypertension was suggested by echocardiography - right ventricular systolic pressure >40 mm Hg. Pulmonary hypertension was defined by right heart catheterization as mean pulmonary artery pressure ≥25 mm Hg and pulmonary artery occlusion pressure ≤15 mm Hg. Results: Right heart catheterization demonstrated pulmonary hypertension in 75{\%} while no pulmonary hypertension was confirmed in 12{\%}. Correlations existed between right ventricular systolic pressure with pulmonary artery systolic pressure (r=0.66; p<0.0001) and mean pulmonary artery pressure (r=0.69; p<0.0001). Bland-Altman analysis illustrated the mean difference between the two methods was 7.75 mm Hg. Conclusions: Pulmonary hypertension occurs commonly in IPF. Accurate classification of pulmonary hemodynamics and degree of pulmonary hypertension severity require right heart catheterization. Prospective screening Doppler echocardiography and pulmonary hypertension therapeutic interventions warrant further prospective study in idiopathic pulmonary fibrosis.",
keywords = "Doppler echocardiography, Interstitial lung disease: Clinical manifestations, Lung fibrosis, Pulmonary fibrosis and hypertension, Right heart catheterization",
author = "Swanson, {Karen L.} and Utz, {James P} and Krowka, {Michael Joseph}",
year = "2008",
month = "4",
language = "English (US)",
volume = "14",
journal = "Medical Science Monitor",
issn = "1234-1010",
publisher = "International Scientific Literature Inc.",
number = "4",

}

TY - JOUR

T1 - Doppler echocardiography - Right heart catheterization relationships in patients with idiopathic pulmonary fibrosis and suspected pulmonary hypertension

AU - Swanson, Karen L.

AU - Utz, James P

AU - Krowka, Michael Joseph

PY - 2008/4

Y1 - 2008/4

N2 - Background: Pulmonary hypertension occurs commonly in patients with interstitial lung disease but is frequently not diagnosed or, if diagnosed, not further evaluated. In this study, we wanted to determine the accuracy of right ventricular systolic pressure measured by transthoracic Doppler echocardiography compared with hemodynamic measurements taken at right heart catheterization in patients with idiopathic pulmonary fibrosis who had suspected pulmonary hypertension. Material/Methods: Right heart catheterization was conducted if pulmonary hypertension was suggested by echocardiography - right ventricular systolic pressure >40 mm Hg. Pulmonary hypertension was defined by right heart catheterization as mean pulmonary artery pressure ≥25 mm Hg and pulmonary artery occlusion pressure ≤15 mm Hg. Results: Right heart catheterization demonstrated pulmonary hypertension in 75% while no pulmonary hypertension was confirmed in 12%. Correlations existed between right ventricular systolic pressure with pulmonary artery systolic pressure (r=0.66; p<0.0001) and mean pulmonary artery pressure (r=0.69; p<0.0001). Bland-Altman analysis illustrated the mean difference between the two methods was 7.75 mm Hg. Conclusions: Pulmonary hypertension occurs commonly in IPF. Accurate classification of pulmonary hemodynamics and degree of pulmonary hypertension severity require right heart catheterization. Prospective screening Doppler echocardiography and pulmonary hypertension therapeutic interventions warrant further prospective study in idiopathic pulmonary fibrosis.

AB - Background: Pulmonary hypertension occurs commonly in patients with interstitial lung disease but is frequently not diagnosed or, if diagnosed, not further evaluated. In this study, we wanted to determine the accuracy of right ventricular systolic pressure measured by transthoracic Doppler echocardiography compared with hemodynamic measurements taken at right heart catheterization in patients with idiopathic pulmonary fibrosis who had suspected pulmonary hypertension. Material/Methods: Right heart catheterization was conducted if pulmonary hypertension was suggested by echocardiography - right ventricular systolic pressure >40 mm Hg. Pulmonary hypertension was defined by right heart catheterization as mean pulmonary artery pressure ≥25 mm Hg and pulmonary artery occlusion pressure ≤15 mm Hg. Results: Right heart catheterization demonstrated pulmonary hypertension in 75% while no pulmonary hypertension was confirmed in 12%. Correlations existed between right ventricular systolic pressure with pulmonary artery systolic pressure (r=0.66; p<0.0001) and mean pulmonary artery pressure (r=0.69; p<0.0001). Bland-Altman analysis illustrated the mean difference between the two methods was 7.75 mm Hg. Conclusions: Pulmonary hypertension occurs commonly in IPF. Accurate classification of pulmonary hemodynamics and degree of pulmonary hypertension severity require right heart catheterization. Prospective screening Doppler echocardiography and pulmonary hypertension therapeutic interventions warrant further prospective study in idiopathic pulmonary fibrosis.

KW - Doppler echocardiography

KW - Interstitial lung disease: Clinical manifestations

KW - Lung fibrosis

KW - Pulmonary fibrosis and hypertension

KW - Right heart catheterization

UR - http://www.scopus.com/inward/record.url?scp=42049120941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42049120941&partnerID=8YFLogxK

M3 - Article

C2 - 18376344

AN - SCOPUS:42049120941

VL - 14

JO - Medical Science Monitor

JF - Medical Science Monitor

SN - 1234-1010

IS - 4

ER -