Dopamine release in the nonhuman primate caudate and putamen depends upon site of stimulation in the subthalamic nucleus

Hoon Ki Min, Erika K. Ross, Hang Joon Jo, Shinho Cho, Megan L. Settell, Ju Ho Jeong, Penelope S. Duffy, Su-Youne Chang, Kevin E. Bennet, Charles D. Blaha, Kendall H Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory Parkinson’s disease. Although DBS has recognized clinical utility, its biologic mechanisms are not fully understood, and whether dopamine release is a potential factor in those mechanisms is in dispute. We tested the hypothesis that STN DBS-evoked dopamine release depends on the precise location of the stimulation site in the STN and the site of recording in the caudate and putamen. We conducted DBS with miniature, scaled-to-animal size, multicontact electrodes and used functional magnetic resonance imaging to identify the best dopamine recording site in the brains of nonhuman primates (rhesus macaques), which are highly representative of human brain anatomy and circuitry. Real-time stimulation-evoked dopamine release was monitored using in vivo fast-scan cyclic voltammetry. This study demon-strates that STN DBS-evoked dopamine release can be reduced or increased by redirecting STN stimulation to a slightly different site.

Original languageEnglish (US)
Pages (from-to)6022-6029
Number of pages8
JournalJournal of Neuroscience
Volume36
Issue number22
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Subthalamic Nucleus
Deep Brain Stimulation
Putamen
Primates
Dopamine
Dissent and Disputes
Brain
Macaca mulatta
Parkinson Disease
Anatomy
Electrodes
Magnetic Resonance Imaging

Keywords

  • Caudate
  • Deep brain stimulation
  • Dopamine
  • Fast-scan cyclic voltammetry
  • Functional magnetic resonance imaging
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dopamine release in the nonhuman primate caudate and putamen depends upon site of stimulation in the subthalamic nucleus. / Min, Hoon Ki; Ross, Erika K.; Jo, Hang Joon; Cho, Shinho; Settell, Megan L.; Jeong, Ju Ho; Duffy, Penelope S.; Chang, Su-Youne; Bennet, Kevin E.; Blaha, Charles D.; Lee, Kendall H.

In: Journal of Neuroscience, Vol. 36, No. 22, 01.06.2016, p. 6022-6029.

Research output: Contribution to journalArticle

Min, Hoon Ki ; Ross, Erika K. ; Jo, Hang Joon ; Cho, Shinho ; Settell, Megan L. ; Jeong, Ju Ho ; Duffy, Penelope S. ; Chang, Su-Youne ; Bennet, Kevin E. ; Blaha, Charles D. ; Lee, Kendall H. / Dopamine release in the nonhuman primate caudate and putamen depends upon site of stimulation in the subthalamic nucleus. In: Journal of Neuroscience. 2016 ; Vol. 36, No. 22. pp. 6022-6029.
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