Donor-transmitted HTLV-1-associated myelopathy in a kidney transplant recipient-case report and literature review

P. Ramanan, P. J. Deziel, S. M. Norby, J. D. Yao, I. Garza, R. R. Razonable

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Clinical disease due to human T cell lymphotropic virus type 1 (HTLV-1), a retrovirus endemic in certain regions of the world, is rarely reported after solid organ transplantation. In 2009, universal deceased donor organ screening for HTLV-1 was discontinued in the United States. We report the first case of donor-derived HTLV-1-associated myelopathy in a kidney transplant recipient from the United States. The patient, who was HTLV-1-seronegative prior to transplantation, likely acquired HTLV-1 infection from a seropositive organ donor. In this era when screening of donors and recipients for HTLV infection is not mandatory, clinicians should be vigilant in recognizing the risk and potential occurrence of this donor-derived infection in recipients with epidemiologic exposures.

Original languageEnglish (US)
Pages (from-to)2417-2421
Number of pages5
JournalAmerican Journal of Transplantation
Volume14
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • Clinical research
  • infection and infectious agents
  • infectious disease
  • practice
  • viral
  • viral: human T-lymphotropic virus (HTLV)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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