Donor-derived Kaposi's sarcoma in a liver-kidney transplant recipient

S. C. Dollard, D. Douglas, S. V. Basavaraju, D. S. Schmid, M. Kuehnert, B. Aqel

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Human herpes virus 8 (HHV-8), also known as Kaposi's sarcoma associated herpesvirus (KSHV), is an oncogenic virus that can cause Kaposi's sarcoma (KS). KS can develop following organ transplantation through reactivation of the recipient's latent HHV-8 infection, or less commonly through donor-derived infection which has higher risk for severe illness and mortality. We describe a case of probable donor-derived KS in the recipient of a liver-kidney transplant. The donor had multiple risk factors for HHV-8 infection. The KS was successfully treated by switching immunosuppression from tacrolimus to sirolimus. With an increasing number of human immunodeficiency virus (HIV)-positive persons seeking organ transplantation and serving as organ donors for HIV-positive recipients, HHV-8 prevalence among donors and recipients will likely increase and with that the risk for post-transplant KS. Predetermination of HHV-8 status can be useful when considering organ donors and recipients with risk factors, although there are currently no validated commercial tests for HHV-8 antibody screening.

Original languageEnglish (US)
JournalAmerican Journal of Transplantation
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Kaposi's Sarcoma
Tissue Donors
Kidney
Liver
Viruses
Organ Transplantation
Virus Diseases
HIV
Transplants
Human Herpesvirus 8
Oncogenic Viruses
Tacrolimus
Sirolimus
Immunosuppression
Transplant Recipients
Mortality
Antibodies
Infection

Keywords

  • Cancer/malignancy/neoplasia
  • Clinical research/practice
  • Infection and infectious agents
  • Infectious disease
  • Kaposi's sarcoma
  • Viral: human herpesvirus 8 (HHV-8)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Dollard, S. C., Douglas, D., Basavaraju, S. V., Schmid, D. S., Kuehnert, M., & Aqel, B. (Accepted/In press). Donor-derived Kaposi's sarcoma in a liver-kidney transplant recipient. American Journal of Transplantation. https://doi.org/10.1111/ajt.14516

Donor-derived Kaposi's sarcoma in a liver-kidney transplant recipient. / Dollard, S. C.; Douglas, D.; Basavaraju, S. V.; Schmid, D. S.; Kuehnert, M.; Aqel, B.

In: American Journal of Transplantation, 01.01.2017.

Research output: Contribution to journalArticle

Dollard, S. C. ; Douglas, D. ; Basavaraju, S. V. ; Schmid, D. S. ; Kuehnert, M. ; Aqel, B. / Donor-derived Kaposi's sarcoma in a liver-kidney transplant recipient. In: American Journal of Transplantation. 2017.
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