Dog model to study the effects of pharmacologic agents on the peripheral circulation

Effect of milrinone

R. W. Lee, R. G. Gay, L. D. Lancaster, M. Olajos, S. Goldman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To study the effects of an inotropic agent, milrinone, on the entire cardiovascular system, we developed an intact dog model to assess the responses of the heart, arterial and venous circulations. At a dose that increased left ventricular dP/dt by 30% (P <.001) from 2033 ± 133 to 2688 ± 140 mm Hg/sec, milrinone caused a decrease (P <.001) in mean aortic pressure from 88.4 ± 3.5 to 73.1 ± 3.0 mm Hg and cardiac output from 148.0 ± 14.6 to 134.5 ± 13.9 ml/kg/min. Heart rate increased (P <.01) from 124 ± 8 to 135 ± 8 beats/min. Systemic vascular resistance did not change. Right atrial pressure and left ventricular enddiastolic pressure decreased (P <.01). Total blood volume did not change but central blood volume decreased (P <.01) from 26.1 ± 0.9 to 22.3 ± 0.5 ml/kg. After milrinone administration, mean circulatory filling pressure decreased (P <.01) by 30% from 7.4 ± 0.4 to 5.0 ± 0.2 mm Hg. Vascular or venous compliance increased (P <.05) slightly from 1.96 ± 0.4 to 2.20 ± 0.1 ml/mm Hg/kg. This was accompanied by an increase (P <.01) in unstressed vascular blood volume of 3.3 ± 0.6 ml/kg. Arterial compliance also increased (P <.05). In summary, milrinone produces an increase in inotropy, arterial vasodilatation and venodilatation as evidenced by the increased venous compliance and unstressed vascular volume. These changes result in a decrease in left ventricular end-diastolic pressure and cardiac output in the normal heart but would be expected to improve the hemodynamics and cardiac output in the setting of a failing heart.

Original languageEnglish (US)
Pages (from-to)1014-1019
Number of pages6
JournalJournal of Pharmacology and Experimental Therapeutics
Volume240
Issue number3
StatePublished - Aug 28 1987
Externally publishedYes

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Milrinone
Blood Volume
Cardiac Output
Dogs
Compliance
Blood Vessels
Atrial Pressure
Ventricular Pressure
Cardiovascular System
Vasodilation
Vascular Resistance
Arterial Pressure
Heart Rate
Hemodynamics
Blood Pressure
Pressure

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Dog model to study the effects of pharmacologic agents on the peripheral circulation : Effect of milrinone. / Lee, R. W.; Gay, R. G.; Lancaster, L. D.; Olajos, M.; Goldman, S.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 240, No. 3, 28.08.1987, p. 1014-1019.

Research output: Contribution to journalArticle

Lee, R. W. ; Gay, R. G. ; Lancaster, L. D. ; Olajos, M. ; Goldman, S. / Dog model to study the effects of pharmacologic agents on the peripheral circulation : Effect of milrinone. In: Journal of Pharmacology and Experimental Therapeutics. 1987 ; Vol. 240, No. 3. pp. 1014-1019.
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abstract = "To study the effects of an inotropic agent, milrinone, on the entire cardiovascular system, we developed an intact dog model to assess the responses of the heart, arterial and venous circulations. At a dose that increased left ventricular dP/dt by 30{\%} (P <.001) from 2033 ± 133 to 2688 ± 140 mm Hg/sec, milrinone caused a decrease (P <.001) in mean aortic pressure from 88.4 ± 3.5 to 73.1 ± 3.0 mm Hg and cardiac output from 148.0 ± 14.6 to 134.5 ± 13.9 ml/kg/min. Heart rate increased (P <.01) from 124 ± 8 to 135 ± 8 beats/min. Systemic vascular resistance did not change. Right atrial pressure and left ventricular enddiastolic pressure decreased (P <.01). Total blood volume did not change but central blood volume decreased (P <.01) from 26.1 ± 0.9 to 22.3 ± 0.5 ml/kg. After milrinone administration, mean circulatory filling pressure decreased (P <.01) by 30{\%} from 7.4 ± 0.4 to 5.0 ± 0.2 mm Hg. Vascular or venous compliance increased (P <.05) slightly from 1.96 ± 0.4 to 2.20 ± 0.1 ml/mm Hg/kg. This was accompanied by an increase (P <.01) in unstressed vascular blood volume of 3.3 ± 0.6 ml/kg. Arterial compliance also increased (P <.05). In summary, milrinone produces an increase in inotropy, arterial vasodilatation and venodilatation as evidenced by the increased venous compliance and unstressed vascular volume. These changes result in a decrease in left ventricular end-diastolic pressure and cardiac output in the normal heart but would be expected to improve the hemodynamics and cardiac output in the setting of a failing heart.",
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