Does presurgical IQ predict seizure outcome after temporal lobectomy? Evidence from the Bozeman Epilepsy Consortium

Gordon J. Chelune, Richard I. Naugle, Bruce P. Hermann, William B. Barr, Max R. Trenerry, David W. Loring, Kenneth Perrine, Esther Strauss, Michael Westerveld

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Purpose: Considerable debate exists concerning whether the presence of low preoperative IQ should be a contraindication for focal resective epilepsy surgery. Methods: We examined the relationship between baseline IQ scores and seizure outcome in 1,034 temporal lobectomy cases from eight epilepsy surgery centers participating in the Bozeman Epilepsy Consortium. Results: Those patients who continued to have seizures following surgery had statistically lower preoperative IQ scores than those who were seizure-free (p < 0.009), but only by 2.3 points. This small but statistically significant relationship was fairly robust; it was observed across seven of the eight centers, and indicates that the findings can be generalized. Among patients with IQ scores of ≤75. 32.8% continued to have seizures following surgery, whereas 23.8% and 16.9% were not seizure free when IQ scores were between 76 and 109 and ≤110, respectively. Relative risk analyses revealed no significant increase in risk among patients with low IQ scores who had no structural lesions other than mesial temporal sclerosis. However, patients with IQ scores of ≤5 had nearly a fourfold (390%) increase in risk for continued seizures as compared with those with higher IQ scores if structural lesions were present. Conclusions: While our results suggest that preoperative IQ scores alone are not good predictors of seizure outcome and should not be used to exclude patients as potential surgical candidates. IQ scores can be useful for counseling patients and their families concerning the relative risks of surgery.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalEpilepsia
Volume39
Issue number3
DOIs
StatePublished - 1998

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Epilepsy
Seizures
Partial Epilepsy
Sclerosis
Counseling

Keywords

  • IQ
  • Prediction
  • Relative risk
  • Seizure outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Chelune, G. J., Naugle, R. I., Hermann, B. P., Barr, W. B., Trenerry, M. R., Loring, D. W., ... Westerveld, M. (1998). Does presurgical IQ predict seizure outcome after temporal lobectomy? Evidence from the Bozeman Epilepsy Consortium. Epilepsia, 39(3), 314-318. https://doi.org/10.1111/j.1528-1157.1998.tb01379.x

Does presurgical IQ predict seizure outcome after temporal lobectomy? Evidence from the Bozeman Epilepsy Consortium. / Chelune, Gordon J.; Naugle, Richard I.; Hermann, Bruce P.; Barr, William B.; Trenerry, Max R.; Loring, David W.; Perrine, Kenneth; Strauss, Esther; Westerveld, Michael.

In: Epilepsia, Vol. 39, No. 3, 1998, p. 314-318.

Research output: Contribution to journalArticle

Chelune, GJ, Naugle, RI, Hermann, BP, Barr, WB, Trenerry, MR, Loring, DW, Perrine, K, Strauss, E & Westerveld, M 1998, 'Does presurgical IQ predict seizure outcome after temporal lobectomy? Evidence from the Bozeman Epilepsy Consortium', Epilepsia, vol. 39, no. 3, pp. 314-318. https://doi.org/10.1111/j.1528-1157.1998.tb01379.x
Chelune, Gordon J. ; Naugle, Richard I. ; Hermann, Bruce P. ; Barr, William B. ; Trenerry, Max R. ; Loring, David W. ; Perrine, Kenneth ; Strauss, Esther ; Westerveld, Michael. / Does presurgical IQ predict seizure outcome after temporal lobectomy? Evidence from the Bozeman Epilepsy Consortium. In: Epilepsia. 1998 ; Vol. 39, No. 3. pp. 314-318.
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