Does Microaneurysm Count Reflect Severity of Early Diabetic RetinoPathy?

Eva M. Kohner; M. Sleightholm; R. N. Bergenstal; P. Morse; A. H. Rubenstein; J. J. Bending; H. Keen; J. C. Pickup; E. M. Kohner; P. M. Lawson; M. A. Sleightholm; R. A. Rizza; F. J. Service; J. C. Trautman; C. B. Canny; M. C. Champion; J. Dupre; N. W. Rodger; J. E. Pucklin; R. S. Sherwin; V. W. Tambourlane; M. Davis; R. Klein

doi:10.1016/S0161-6420(86)33692-3

Does Microaneurysm Count Reflect Severity of Early Diabetic RetinoPathy?

Eva M. Kohner, M. Sleightholm, R. N. Bergenstal, P. Morse, A. H. Rubenstein, J. J. Bending, H. Keen, J. C. Pickup, E. M. Kohner, P. M. Lawson, M. A. Sleightholm, R. A. Rizza, F. J. Service, J. C. Trautman, C. B. Canny, M. C. Champion, J. Dupre, N. W. Rodger, J. E. Pucklin, R. S. SherwinV. W. Tambourlane, M. Davis, R. Klein

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

In a group of 55 insulin-dependent diabetic patients with early diabetic retinopathy, microaneurysm counts from fluorescein angiograms were related to the level and severity of retinopathy derived by grading eight standard stereo color photographs as used in the Early Treatment of Retinopathy Study (ETDRS). All patients were studied at 0, 8, and 24 months. Significant correlations were present between both “definite” and “possible” microaneurysm count and retinopathy level of the eye studied and the mean retinopathy level of the two eyes, at all three time intervals, (P < 0.05-< 0.001). Similarly, there were significant correlations between microaneurysm counts and severity of the following lesions: microaneurysms and haemorrhages, cotton-wool spots (P < 0.05< 0.001); to a lesser degree, severity of hard exudates (P < 0.1-< 0.001) and intraretinal microvascular abnormalities (P not significant-< 0.001). There was no correlation between microaneurysm count and venous abnormalities (as at no time were there more than 11 eyes with any venous abnormality). We conclude that microaneurysm counts from fluorescein angiograms accurately reflect the severity of important signs in early diabetic retinopathy.

Original language	English (US)
Pages (from-to)	586-589
Number of pages	4
Journal	Ophthalmology
Volume	93
Issue number	5
DOIs	https://doi.org/10.1016/S0161-6420(86)33692-3
State	Published - 1986

Keywords

early diabetic retinopathy
fluorescein angiograms
microaneurysms

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/S0161-6420(86)33692-3

Cite this

Kohner, E. M., Sleightholm, M., Bergenstal, R. N., Morse, P., Rubenstein, A. H., Bending, J. J., Keen, H., Pickup, J. C., Kohner, E. M., Lawson, P. M., Sleightholm, M. A., Rizza, R. A., Service, F. J., Trautman, J. C., Canny, C. B., Champion, M. C., Dupre, J., Rodger, N. W., Pucklin, J. E., ... Klein, R. (1986). Does Microaneurysm Count Reflect Severity of Early Diabetic RetinoPathy? Ophthalmology, 93(5), 586-589. https://doi.org/10.1016/S0161-6420(86)33692-3

Kohner, EM, Sleightholm, M, Bergenstal, RN, Morse, P, Rubenstein, AH, Bending, JJ, Keen, H, Pickup, JC, Kohner, EM, Lawson, PM, Sleightholm, MA, Rizza, RA, Service, FJ, Trautman, JC, Canny, CB, Champion, MC, Dupre, J, Rodger, NW, Pucklin, JE, Sherwin, RS, Tambourlane, VW, Davis, M & Klein, R 1986, 'Does Microaneurysm Count Reflect Severity of Early Diabetic RetinoPathy?', Ophthalmology, vol. 93, no. 5, pp. 586-589. https://doi.org/10.1016/S0161-6420(86)33692-3

@article{70f72ea9da0d4e8d943cfabeffe5ece8,

title = "Does Microaneurysm Count Reflect Severity of Early Diabetic RetinoPathy?",

abstract = "In a group of 55 insulin-dependent diabetic patients with early diabetic retinopathy, microaneurysm counts from fluorescein angiograms were related to the level and severity of retinopathy derived by grading eight standard stereo color photographs as used in the Early Treatment of Retinopathy Study (ETDRS). All patients were studied at 0, 8, and 24 months. Significant correlations were present between both “definite” and “possible” microaneurysm count and retinopathy level of the eye studied and the mean retinopathy level of the two eyes, at all three time intervals, (P < 0.05-< 0.001). Similarly, there were significant correlations between microaneurysm counts and severity of the following lesions: microaneurysms and haemorrhages, cotton-wool spots (P < 0.05< 0.001); to a lesser degree, severity of hard exudates (P < 0.1-< 0.001) and intraretinal microvascular abnormalities (P not significant-< 0.001). There was no correlation between microaneurysm count and venous abnormalities (as at no time were there more than 11 eyes with any venous abnormality). We conclude that microaneurysm counts from fluorescein angiograms accurately reflect the severity of important signs in early diabetic retinopathy.",

keywords = "early diabetic retinopathy, fluorescein angiograms, microaneurysms",

author = "Kohner, {Eva M.} and M. Sleightholm and Bergenstal, {R. N.} and P. Morse and Rubenstein, {A. H.} and Bending, {J. J.} and H. Keen and Pickup, {J. C.} and Kohner, {E. M.} and Lawson, {P. M.} and Sleightholm, {M. A.} and Rizza, {R. A.} and Service, {F. J.} and Trautman, {J. C.} and Canny, {C. B.} and Champion, {M. C.} and J. Dupre and Rodger, {N. W.} and Pucklin, {J. E.} and Sherwin, {R. S.} and Tambourlane, {V. W.} and M. Davis and R. Klein",

note = "Funding Information: Supported by the Kroc Foundation.",

year = "1986",

doi = "10.1016/S0161-6420(86)33692-3",

language = "English (US)",

volume = "93",

pages = "586--589",

journal = "Ophthalmology",

issn = "0161-6420",