Does hemochromatosis predispose to celiac disease? A study of 29,096 celiac disease patients

Jonas F. Ludvigsson, Joseph A Murray, Paul C. Adams, Maria Elmberg

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and aim. Case reports suggest an association between hereditary hemochromatosis (HH) and celiac disease (CD), but estimates of association are lacking. We estimated the association between HH and CD in a population-based study. Material and methods. Case-control study. We identified 29,096 individuals with biopsy-verified CD (equal to villous atrophy, Marsh stage III) through biopsy reports from all 28 pathology departments in Sweden. We then investigated the risk of a clinical diagnosis of HH in CD and in 144,522 controls matched for age, sex, county and calendar year. Conditional logistic regression was used to calculate odds ratios (ORs) for CD in patients with HH. Results. HH was seen in 30 patients with CD and in 60 matched controls. HH was hence associated with an increased risk of CD (OR = 2.30; 95% CI = 1.53-3.45). Restricting HH to individuals with at least two records of HH, the OR for CD was 2.54 (95% CI = 1.57-4.11), with a similar risk estimate when we only looked at HH diagnosed before CD (and matched date in controls) (OR = 2.64; 95% CI = 1.24-5.60). Conclusion. HH seems to be associated with an increased risk of CD.

Original languageEnglish (US)
Pages (from-to)176-182
Number of pages7
JournalScandinavian Journal of Gastroenterology
Volume48
Issue number2
DOIs
StatePublished - Feb 2013

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Hemochromatosis
Celiac Disease
Odds Ratio
Inborn Genetic Diseases
Biopsy
Wetlands
Sweden
Atrophy
Case-Control Studies
Logistic Models
Pathology

Keywords

  • Autoimmunity
  • Celiac
  • Hemochromatosis
  • Inflammation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Does hemochromatosis predispose to celiac disease? A study of 29,096 celiac disease patients. / Ludvigsson, Jonas F.; Murray, Joseph A; Adams, Paul C.; Elmberg, Maria.

In: Scandinavian Journal of Gastroenterology, Vol. 48, No. 2, 02.2013, p. 176-182.

Research output: Contribution to journalArticle

Ludvigsson, Jonas F. ; Murray, Joseph A ; Adams, Paul C. ; Elmberg, Maria. / Does hemochromatosis predispose to celiac disease? A study of 29,096 celiac disease patients. In: Scandinavian Journal of Gastroenterology. 2013 ; Vol. 48, No. 2. pp. 176-182.
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