Does exercise training alter myocardial creatine kinase MB isoenzyme content?

T. D. Miller, P. J. Rogers, Brent A Bauer, J. F. O'Brien, R. W. Squires, Kent R Bailey, A. A. Bove

Research output: Contribution to journalArticle

8 Scopus citations


Skeletal muscle biopsies from highly trained endurance athletes have been shown to contain an increased percentage of the creatine kinase MB (CK-MB) isoenzyme, which has been attributed to continuous regeneration of the skeletal muscle fibers in response to exercise-induced injury. The purpose of this study was to determine whether myocardium undergoes a similar degenerative-regenerative process as a result of exercise training. Fifteen mongrel dogs underwent a 12-wk period of training (N = 8) or cage confinement (N = 7). The animals were then sacrificed, and samples of left and right ventricular myocardium were analyzed for total CK activity and CK-MB isoenzyme content. Percentages of CK-MB were slightly but insignificantly higher from both ventricles of exercise-trained as compared with cage-confined dogs: left ventricle, 4.6 ± 0.6% vs 3.3 ± 0.6%, respectively (P = 0.15); right ventricle, 4.0 ± 0.4% vs 3.0 ± 0.8%, respectively (P = 0.29). We conclude that chronic exercise training does not induce physiologically important degenerative changes in myocardium.

Original languageEnglish (US)
Pages (from-to)437-440
Number of pages4
JournalMedicine and Science in Sports and Exercise
Issue number4
StatePublished - 1989

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Miller, T. D., Rogers, P. J., Bauer, B. A., O'Brien, J. F., Squires, R. W., Bailey, K. R., & Bove, A. A. (1989). Does exercise training alter myocardial creatine kinase MB isoenzyme content? Medicine and Science in Sports and Exercise, 21(4), 437-440.